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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v3.i3.50
pages 243-251

Effect of Streptozotocin-Induced Diabetes and Incomplete Global Cerebral Ischemia on Apoptosis in the Rat Thymus

A. V. Tkachuk
Bukovinian State Medical University, Chernivtsi, Ukraine

RÉSUMÉ

The effect of incomplete global cerebral ischemia-reperfusion on the activity in pro-and anti-apoptotic processes in the thymocytes by the intensity of the p53 and Bcl-2 protein expression was investigated. It has been shown that in the cortical zone of the rat thymus with four-month diabetes mellitus, as well as in control rats and animals with diabetes mellitus after cerebral ischemia-reperfusion, anti-apoptotic processes dominated. In the medullary area of the gland in rats with diabetes, anti-apoptotic mechanisms either complicated or uncomplicated with cerebral ischemia-reperfusion also predominated, but to a lesser extent than in the cortical zone.


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