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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i4.50
pages 323-332

Morphofunctional Changes in Vascular Endothelium of Rat Diencephalon in Experimental Ischemia-Reperfusion against the Background of Diabetes Mellitus

Taras M. Boychuk
Higher State Educational Establishment of Ukraine "Bukovinian State Medical University," Chernivtsi, Ukraine
Taras P. Savchuk
Bukovinian Medical University, Chernivtsi, Ukraine


The effect of bilateral carotid ischemia-reperfusion on the morphofunctional state of the vascular endothelium in the limbic-hypothalamic complex has been studied. It has been found that in control rats, lower density of endothelial cells in early ischemic-reperfusion period was relative, due to cell swelling, whereas absolute cell density increased on the 12th day. The capillary endothelial cells in all brain structures manifested increased content of total RNA in both periods of observation. Animals with diabetes mellitus, have no early response of the morphofunctional state of endotheliocytes to ischemia-reperfusion,, except for vessels of the ventromedial nucleus of the hypothalamus, and the late response is limited by the growth of RNA content in the cells.

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