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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i4.70
pages 345-354

Cardiac Hypoxic Remodeling and Preconditioning Impact on Protein Kinase B (Akt) Expression in Left and Right Heart Ventricles

Alla G. Portnychenko
International Center for Astronomical, Medical and Ecological Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine; Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetiana Yu. Lapikova-Bryhinska
International Centre for Astronomical, Medical and Ecological Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
Marina I. Vasilenko
Bogomolets Institute of Physiology, National academy of Sciences of Ukraine, Kyiv, Ukraine; International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Kyiv, Ukraine
Georgiy Portnichenko
Bogomolets Institute of Physiology, National Academy of Science of Ukraine, Kyiv, Ukraine
Leonid Maslov
FGBO Research Institute of Cardiology, Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia
Oleksiy O. Moibenko
International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Department of Experimental Cardiology, Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine

RÉSUMÉ

The impact of hypoxic preconditioning and remodeling on the expression of protein kinase B (Akt) in the heart ventricles was investigated. Male Wistar rats, the residents of plains or middle altitude (2100 m above sea level), were exposed to hypoxic preconditioning by "lifting" in the barochamber at the "altitude" of 5.600 m for 3 h. In the right and left ventricles of the heart, Akt protein expression was determined by Western blotting. It has been shown, that hypoxic preconditioning causes the induction of Akt kinase in the ventricles during the period of delayed cardioprotection (1-3 days after preconditioning). Myocardial remodeling induced by chronic hypoxia in middle altitude was associated with elevated Akt expression in the myocardium, more pronounced in the left ventricle. Progression of hypoxic myocardial remodeling, found in a part of the animals, was accompanied by a reduction of the cell hypoxic reactivity, including Akt induction in response to preconditioning. Thus, Akt kinase is involved in the mechanisms of hypoxia induced late preconditioning and myocardial remodeling in chronic hypoxia. Inhibitory regulatory mechanism was found to limit the induction of Akt in myocardium after remodeling.


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