Abonnement à la biblothèque: Guest
International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

An Inhibitor of Mitochondrial Na+ − Ca2+ Exchanger CGP37157 Produces Depolarization of the Endothelial Cells with Membrane Potential Oscillations

Volume 3, Numéro 1, 2012, pp. 19-28
DOI: 10.1615/IntJPhysPathophys.v3.i1.30
Get accessGet access

RÉSUMÉ

We studied the effects of CGP37157, an inhibitor of mitochondrial Na+ − Ca2+ exchanger and cyclosporine A, an inhibitor of mitochondrial permeability transition pore opening,,on the membrane potential and electrical responses of intact endothelial cells from rat aorta and cultured endothelial cells. Cyclosporine A did not alter either the membrane potential of unstimulated endothelium, or the hyperpolarization in response to acetylcholine and histamine. CGP37157 induced membrane depolarization of unstimulated endothelial cells, and inhibited the sustained hyperpolarization in response to acetylcholine and histamine. In the presence of CGP37157, a transient hyperpolarization was followed by a depolarization accompanied by membrane potential oscillations of large amplitude. The latter was not observed in calcium-free medium. Our results indicate on a modulating effect of CGP37157 on endothelial cells membrane potential at rest and electrical responses to endothelium-dependent vasodilators. Possible mechanisms of CGP37157 action are discussed.

2324 Vues d'articles 5 Téléchargements d'articles Métrique
2324 VUES 5 TÉLÉCHARGEMENTS Google
Scholar
CITATIONS

Articles avec un contenu similaire:

Nitric Oxide as Possible Regulator of Energy-Dependent Ca2+ Transport in Mitochondria of Uterine Smooth Muscle International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 2
Sergiy O. Kosterin, G. V. Danylovych , Oksana V. Kolomiets, Yuriy V. Danylovych
The Role of TRPV4 Cation Channels in Regulation of Phenylephrine-Induced Contraction of Rat Pulmonary Artery International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 2
Mariia Melnyk, Dariia Dryn, Anatoly I. Soloviev, Hongzhen Hu, Alexander Zholos, Ihor Kizub
The Role of Calcium Uniporter in Calcium Homeostasis of Extraorbital Lacrimal Gland Secretory Cells International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 3
Anna B. Kotliarova, Volodymyr V. Manko , Volodymyr M. Merlavsky, Olga M. Dorosh
Hydrogen Sulfide Inhibits Calcium-Induced Mitohondrial Permeability Transition Pore Opening in the Heart of Adult and Old Rats International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Olena M. Semenykhina
Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 3
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva

Dernier numéro

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain