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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i5.10
pages 415-426

Specificity of the Immunomodulating Activity of Sasa veitchii (Japanese Folk Medicine Kumazasa) to Fungal Polysaccharides

Wataru Sato
Tokyo University of Pharmacy and Life Science, Tokyo
Kazuo Takeshita
Hoshi Pharmaceutical Co., Ltd., Tokyo, Japan
Masamichi Tsuboi
Hoshi Pharmaceutical Co., Ltd, Tokyo
Masato Kanamori
Hoshi Pharmaceutical Co., Ltd, Tokyo
Ken-Ichi Ishibashi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

RÉSUMÉ

Many plant extracts are used as well-known folk medicines and exhibit various biological activities that are beneficial to human health. These extracts contain polysaccharides, and some are pathogen-associated molecular patterns (PAMPs) that stimulate innate as well as acquired immune systems. In the present study, the cooperative effects of PAMPs and bamboo water-soluble methanol precipitation (BWMP) in a macromolecular fraction of the hot water extract of Sasa veitchii (in Japanese folk medicine, known as Kumazasa; family Poaceae) were analyzed in vitro using the spleen or bone marrow cells of mice. The splenocytes of male DBA/2 and C57BL/6 mice were cultured with BWMP in the presence or absence of PAMPs, and responses were assessed by measuring cytokines. BWMP inhibited the production of interferon gamma (IFN−γ) by not only toll like receptors (TLRs), but also the C-type lectin receptors (CLRs) dectin-1 and dectin-2. BWMP also inhibited the autologous production of IFN−γ in the splenocyte culture. These results suggested that BWMP may inhibit the signaling pathways of PAMPs, but not ligand-receptor interactions. In contrast, BWMP did not inhibit the production of cytokines by dendritic cells. These results indicated that the inhibition of IFN−γ by BWMP was mediated through the cell-to-cell interactions of splenic cells during cultivation.


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