Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.211 Facteur d'impact sur 5 ans: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v19.i3.50
pages 233-242

Effect of Hispolon from Phellinus lonicerinus (Agaricomycetes) on Estrogen Receptors, Aromatase, and Cyclooxygenase II in MCF-7 Breast Cancer Cells

Junzhi Wang
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Hubei Engineering Research Center of Biological Ferment, Yichang, Hubei, China
Beiyan Chen
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China
Fang Hu
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China
Xueling Zou
Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang, China
Haili Yu
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China
Jinyu Wang
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China
Haibo He
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Hubei Engineering Research Center of Biological Ferment, Yichang, Hubei, China
Hongqi Zhang
Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang, China
Wenfeng Huang
Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang, China

RÉSUMÉ

Phytoestrogen has previously been proposed as an alternative to hormone replacement therapy. Hispolon has been found to have phytoestrogenic properties. However, the possible effects of hispolon on estrogen receptors and other related molecules remain to be determined. This study was performed mainly to confirm the estrogenic function of hispolon as it relates to estrogen receptors, aromatase, and cyclooxygenase 2 (COX-2). Hispolon was shown to increase the serum 17β-estradiol in vivo. Immunohistochemical staining methods showed that hispolon exhibited a biphasic effect on ERα/β and aromatase expression in MCF-7 cells. Hispolon could also significantly inhibit aromatase activity, assessed using the enzyme-linked immunosorbent assay. Western blotting showed that COX-2 and aromatase could be inhibited by hispolon. These results further prove the phytoestrogenic features of hispolon and explore some pharmacological mechanisms that suggest that hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.


Articles with similar content:

Calcium-Sensing Receptor Arbitrates Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells via the G Protein-PLC-IP3 Pathway
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Zhengying Duan, Ting Gao, Zuowu Jiao, Wei Liu, Yongxiang Tian, Keli Yang, Hui Zhang, Khalid Mehmood, Zhenyu Chang, Fangyan Yuan, Zewen Liu, Muhammad Taslim Ghori, Xiaoying Pei, Rui Guo, Muhammad Ijaz

Nitric Oxide−Releasing Hybrid Drugs Target Cellular Processes Through S-Nitrosylation
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Khosrow Kashfi

Is Cyclooxygenase-2 Important in Skin Carcinogenesis?
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Susan M. Fischer

Chemopreventive Properties of Mushrooms Against Breast Cancer and Prostate Cancer
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Y.-C. Yuan, K. Lui, J. Ye, G. Hur, D. Smith, S. Chen, S. Phung, S. Kwok, K. Karlsberg, S. Oh

Chemopreventive Action of Diclofenac in Dimethybenzanthracene Induced Lung Cancer in Female Wistar Rat
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
Sankar Nath Sanyal, Poonam Thakur