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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019032660
pages 1019-1031

The Antioxidative, Anti-inflammatory, and Liver-Protective Effects of Mycelia Selenium Polysaccharides from the Deep Root Mushroom, Oudemansiella radicata (Agaricomycetes)

Hui Liu
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China
Qihang Yang
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China
Zheng Gao
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China
Yongfa Zhu
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China
Jianjun Zhang
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China
Le Jia
College of Life Science, Shandong Agricultural University, Taiwan, 271018, PR China


In the present work, the mycelia polysaccharides (MPS) and mycelia selenium polysaccharides (MSPS) were obtained from Oudemansiella radicata. Their antioxidative, antiinflammatory, and hepatic-protective effects on lipopolysaccharide-induced liver damage in mice were investigated. The results showed that MSPS had potential effects on relieving liver injury by monitoring the serum levels of hypersensitive C-reactive protein, complement 3, and serum enzyme activities (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase), enhancing the antioxidant enzymes abilities (superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant capacity), and decreasing the lipid peroxidation (lipid peroxidation and malondialdehyde). Furthermore, the in vitro scavenging results indicated that the inhibition effects of MSPS on hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl radicals reached 63.00 ± 3.59% and 68.86 ± 3.97%, respectively, at 1000 mg/L. These conclusions demonstrated that both MPS and MSPS might be suitable for functional foods and natural drugs for preventing acute liver damage.


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