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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Potential Role of Medicinal Mushrooms in Breast Cancer Treatment: Current Knowledge and Future Perspectives

Volume 7, Numéro 1&2, 2005, pp. 141-146
DOI: 10.1615/IntJMedMushr.v7.i12.140
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RÉSUMÉ

Breast cancer has become the most common invasive form of female cancer in the last few decades. Statistics show that the rate of newly diagnosed cases of breast cancer is rising every year depending on age, race, heredity, and ethnicity. The National Cancer Institute of US and mainly the Division of Cancer Control and Population Sciences (DCCPS) promote and conduct research that also identifies the economic, social, cultural, psychological, behavioral, and biological mechanisms that are potential reasons for breast cancer development. Advanced breast cancers do not respond well to therapy, and their gene expression arouses uncontrolled growth. Although estrogen-receptor (ER)-positive breast cancers respond to hormonal therapy, the treatment of ER-negative cancers is more complicated because of their ability for developing resistance to drugs. Lack of molecular targets in estrogen receptor-negative breast cancer is a major therapeutic hurdle. It has been known that NF-κB is significantly important in the processes of inflammation, cell survival, transformation, and oncogenesis, as well as in the etiology of breast cancer. A theory exists, according to which ER-negative breast cancer cells depend on NF-κB for aberrant cell proliferation and simultaneously avoid apoptosis, suggesting that NF-κB can be used as a potential molecular target in breast cancer treatment. Studies on new anticancer treatments and other medicinal substances from mushrooms have been significantly expanded in the last few years. This is mainly because they contain bioactive polymers such as polysaccharides and polysaccharide/protein complexes, secondary metabolites, and enzymes isolated from fruit bodies, mycelia, and culture broth. There are data showing the potential activity of medicinal mushrooms in breast cancer treatment. Ganoderma lucidum has shown the most significant inhibitory effect on NF-κB activity in highly invasive breast cancer cells. Other medicinal mushrooms that have also been reported to produce biologically active substances, have been tested in in vivo or in vitro, and have demonstrated breast cancer inhibitory activity are Agaricus bisporus, A. brasiliensis, Trametes versicolor, Grifola frondosa, Inonotus obliquus, Lentinus edodes, Leucoagaricus americanus, Pleurotus ostreatus, Sparassis crispa, etc.

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