Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024975
pages 1053-1060

A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells

Mingxing Wang
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China
Yanqiu Zhang
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China
Xulang Xiao
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Duoduo Xu
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Yang Gao
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Qipin Gao
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China

RÉSUMÉ

Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H. erinaceus a polysaccharide with anti–gastric ulcer and antigastritis activity, but its effects on gastric malignancy have not been elucidated. We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N'-nitro-N-nitrosoguanidine. We observed that the polysaccharide potently induced cell apoptosis and cell cycle arrest at the G0/G1 phase in the MC cell line but did not have any effect on the GES-1 cell line at the same doses. Further mechanistic studies revealed that the polysaccharide exerted its activity through an apoptosis-associated pathway by modulating the expression of Bax, Bcl-2, and caspase-3. Differential effects of the polysaccharide on the GES-1 and MC cell lines indicate that the polysaccharide was effective in preventing gastric cancer progression.


Articles with similar content:

The Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) Substances Interfere with H2O2 Induction of the NF-κB Pathway through Inhibition of IκBα Phosphorylation in MCF7 Breast Cancer Cells
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 1
Solomon P. Wasser, Nili Ruimi, Abraham Reznick, Mikheil D. Asatiani, Eviatar Nevo, Jamal A. Mahajna
Bioactive Components of Ganoderma lucidum (W.Curt.:Fr.) Lloyd Can Induce Apoptosis of Tumor Cells
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Martin Zimmerman-Kordmann, Jing-Song Zhang, Hua Fan, Werner Reutter, Qing-jiu Tang Tang
Healing Effect of Ethanolic Extracts from Mycelia of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), with High Ergothioneine Content in UVB-Irradiated Human Skin Fibroblasts
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 5
Shin-Yi Lin, Jeng-Leun Mau, Shu-Yao Tsai
Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Wen-long Zhang, Yuan-Song Bai, Zhang-zhen Shi, Dan Cong, Ya-nan Zhao
Chemopreventive Properties of Mushrooms Against Breast Cancer and Prostate Cancer
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Y.-C. Yuan, K. Lui, J. Ye, G. Hur, D. Smith, S. Chen, S. Phung, S. Kwok, K. Karlsberg, S. Oh