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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i1.20
14 pages

Antitumor Activity and Hematopoietic Response of a b-Glucan Extracted from an Edible and Medicinal Mushroom Sparassis crispa Wulf.: Fr. (Aphyllophoromycetideae)

Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Toshie Harada
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Shinya Masuzawa
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Mitsuhiro Nakajima
Minahealth Co. Ltd., Saitama, Japan
Toshiro Yadomae
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

RÉSUMÉ

Sparassis crispa Wulf.: Fr. is an edible and medicinal mushroom recently cultivated in Japan. It contains a high content (~ 40%) of 6-branched 1,3-b-D-glucan showing antitumor activity. Oral administration of the (b-glucan fraction CA1, extracted with cold sodium hydroxide, enhanced the hematopoietic response in cyclophosphamide (CY)-induced leukopenic mice assessed by white blood cell count. Analyzing the leukocyte population by flow cytometry, the rate of leukocyte recovery in CY-administered mice was different in each population, such as granulocyte, monocyte, natural killer cell, В cell, Т cell, and so on. Administration of CA1 modulated the recovery rate of each population. In Peyer's patches, recovery of the T/B ratio was faster than in the control group. In in vitro, CY-treated spleen cell culture, interleukin-6 and interferon-g production was enhanced by CA1 treatment. These facts strongly suggested that the enhanced hematopoietic response by CA1 is due to enhanced cytokine production.


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