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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i1.50
6 pages

Neurotropic Effect of the Edible and Medicinal Mushroom Lentinus edodes (Berk.) Sing. Extracts on the Neurons of Hippocampal Slices in Rats

Mykhaylo Moldavan
Oregon Health and Science University
Anna A. Grodzinskaya
Department of Spore Plants, M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Tereshchenkivska str. 2, Kiev, GSP-1, 01601, Ukraine
Victor M. Storozhuk
Department of Brain Physiology, A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoltza str. 4, Kiev 01024

RÉSUMÉ

Effects of Lentinus edodes (Berk.) Sing. extract on the spike activity of 28 pyramidal neurons from the CA1 region of the albino rat hippocampus were studied. In 12 (43%) neurons the extract application resulted in inhibition; in 4 (14%) neurons an insignificant increase in the spike discharge frequency was observed; and 12 (43%) cells showed no response. Latency and duration were as follows: for inhibitory responses (71 ± 14 s, 192 ± 26 s), for excitatory responses (63 ± 19 s, 116 ± 30 s). During washing, 11 neurons showed periodical group spike discharges that occurred on the average for 182 ± 35 s, but in one neuron they lasted for 34 minutes. It was suggested that in most cases the extract action caused a hyperpolarization of neuron membranes that during washing was replaced by a depolarization that was associated with the emergence of group discharges. An antagonist of GABA receptors, bicuculline, and an antagonist of 5-HT2/5-HT1C serotonin receptors, ritanserin, blocked an inhibitory effect of the extract partially or completely. This indicates that GABA or its agonist and substances that may activate serotonin receptors are involved in inhibition of neuron spike responses during the extract application.


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