Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Inhibits Candida Biofilms: A Metabolomic Approach
RÉSUMÉ
This article presents a comparative gas chromatography (GC)−mass spectrometry (MS)−based metabolomic analysis of mycelia and fruiting bodies of the medicinal mushroom Ganoderma lucidum. Three aqueous extracts−mycelia, fruiting bodies, and a mixture of them−and their sequential fractions (methanolic and ethyl acetate), prepared using an accelerated solvent extractor, were characterized by GC-MS to determine volatile organic compounds and by high-performance thin-layer chromatography to quantify ascorbic acid, a potent antioxidant. In addition, these extracts and fractions were assessed against Candida albicans and C. glabrata biofilms via the XTT reduction assay, and their antioxidant potential was evaluated. Application of chemometrics (hierarchical cluster analysis and principal component analysis) to GC data revealed variability in volatile organic compound profiles among G. lucidum extracts and fractions. The mycelial aqueous extract demonstrated higher anti-Candida activity and ascorbic acid content among all the extracts and fractions. Thus, this study illustrates the preventive effect of G. lucidum against C. albicans and C. glabrata biofilms along with its nutritional value.
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Mishra Jigni, Rajput Rakhee, Singh Kaushlesh, Puri Sanjeev, Goyal Meenakshi, Bansal Anju, Misra Kshipra, Antibacterial Natural Peptide Fractions from Indian Ganoderma lucidum , International Journal of Peptide Research and Therapeutics, 24, 4, 2018. Crossref
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Rakhee , Mishra Jigni, Sharma Raj K., Misra Kshipra, Characterization Techniques for Herbal Products, in Management of High Altitude Pathophysiology, 2018. Crossref
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Bhardwaj Anuja, Misra Kshipra, Ganoderma sp.: The Royal Mushroom for High-Altitude Ailments, in Management of High Altitude Pathophysiology, 2018. Crossref
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Mishra Jigni, Bhardwaj Anuja, Pal Mamta, Rajput Rakhee, Misra Kshipra, High performance thin layer chromatography hyphenated with electrospray mass spectrometry for evaluation of nucleobases in two traditional Chinese medicinal mushrooms: A metabolomic approach, Journal of Liquid Chromatography & Related Technologies, 41, 15-16, 2018. Crossref
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Chou Chun‐Hsu, Tsai Ming‐Shiun, Lu Hsin‐Yu, Chang Chao‐Kai, Cheng Kuan‐Chen, Jhan Mei‐Hsin, Hsieh Chang‐Wei, Enzymatic hydrolysates obtained from Trametes versicolor polysaccharopeptides protect human skin keratinocyte against AAPH‑induced oxidative stress and inflammatory , Journal of Cosmetic Dermatology, 18, 6, 2019. Crossref
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Dizeci Naz, Onar Okan, Karaca Basar, Demirtas Nergiz, Coleri Cihan Arzu, Yildirim Ozlem, Comparison of the chemical composition and biological effects of Clitocybe nebularis and Infundibulicybe geotropa, Mycologia, 2021. Crossref
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Al-Obaidi Jameel R., Jambari Nuzul Noorahya, Ahmad-Kamil E. I., Mycopharmaceuticals and Nutraceuticals: Promising Agents to Improve Human Well-Being and Life Quality, Journal of Fungi, 7, 7, 2021. Crossref
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Mishra Jigni, Khan Washim, Ahmad Sayeed, Misra Kshipra, Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia, Frontiers in Pharmacology, 12, 2021. Crossref
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Mishra Jayshree, Simonsen Randall, Kumar Narendra, Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity, Journal of Biological Chemistry, 294, 48, 2019. Crossref
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Singh Ranjeet, Singh Avneet Pal, Dhingra Gurpaul Singh, Shri Richa, Ganoderma: A Propitious Medicinal Poroid Mushroom, in Bioactive Natural products in Drug Discovery, 2020. Crossref
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Zou Pan, Guo Yongze, Ding Shu, Song Zhaowei, Cui Hanyuan, Zhang Yue, Zhang Zhijun, Chen Xiaoming, Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars, Molecules, 27, 19, 2022. Crossref