Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes)
RÉSUMÉ
Excessive glucose concentrations in blood and cells promote the intensification of auto-oxidation. This is one of the mechanisms through which free radicals form in hyperglycemia. As a result of hyperglycemia, oxidative stress develops and lipid peroxidation (LPO) is enhanced. Erythrocytes are particularly susceptible to reactive oxygen species and LPO, which can violate cell functions. This article describes the analysis of the influence of mycelia from the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum on the enzymatic link of the antioxidant system in rat erythrocytes under streptozotocin-induced diabetes mellitus. Oxidative stress was strengthened in red blood cells of diabetic rats, as evidenced by decreased activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, and by increased amounts of thiobarbituric acid–positive products, which are markers of LPO. Administration of A. brasiliensis and G. lucidum submerged cultivated mycelial powder to animals with streptozotocin-induced diabetes restored superoxide dismutase, catalase, and glutathione peroxidase activity and reduced the amounts of thiobarbituric acid–positive products to control values, but did not affect the activity of glutathione reductase.
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Fedotov O. V. , Phenolic substances as regulators of the intensity of lipid peroxidation processes of the strains Pleurotus eryngii, Fistulina hepatica and Agrocybe cylindracea , Regulatory Mechanisms in Biosystems, 11, 2, 2020. Crossref
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Fedotov O. V. , Usikova Z. L. , Modification of isolation methods and physico-biochemical properties of preparations of fungal oxidoreductases , Regulatory Mechanisms in Biosystems, 11, 2, 2020. Crossref
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Fedotov O. V. , Usikova Z. L. , Modification of isolation methods and physico-biochemical properties of preparations of fungal oxidoreductases , Regulatory Mechanisms in Biosystems, 11, 2, 2020. Crossref
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Zeb Mehreen, Lee Chow H., Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America, Molecules, 26, 2, 2021. Crossref
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Chan Sze Wa, Tomlinson Brian, Chan Paul, Lam Christopher Wai Kei, The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk, Pharmaceutical Biology, 59, 1, 2021. Crossref
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Arunachalam Karuppusamy, Sreeja Puthanpura Sasidharan, Yang Xuefei, The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance, Frontiers in Pharmacology, 13, 2022. Crossref