Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i9.90
pages 891-901

Antitumor and Immunomodulating Activities of Exopolysaccharide Produced by Big Cup Culinary- Medicinal Mushroom Clitocybe maxima (Higher Basidiomycetes) in Liquid Submerged Culture

Shu-Hui Hu
Department of Nutrition and Dietetics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Peter Chi Keung Cheung
School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Raw-Pou Hung
Department of Dietetics, Zhongxiao Branch, Taipei City Hospital, Nangang District, Taipei, Taiwan
Yu-Kuei Chen
Department of Food Science and Nutrition, MeiHo University, Neipu Shiang, Pingtung, Taiwan
Jinn-Chyi Wang
Department of Food Science and Technology, Tajen University, Shin-Erh Village, Yen-Pu Shiang, Pingtung, Taiwan
Sue-Joan Chang
Department of Life Science, National Cheng Kung University, Tainan, Taiwan, 701

RÉSUMÉ

Water-soluble polysaccharides extracted from mushrooms have been found to have some physiological effects. In this study, exopolysaccharides (EPSs) were extracted by alcohol precipitation from cultivated broth of the mushroom Clitocybe maxima. EPSs with molecular weights of 104 and 105 Da were obtained by ultrafiltration; they are referred to as EPA and EPB, respectively. The major components of these EPSs were glucose, galactose, mannose, rhamnose, and arabinose. ICR mice with artificially induced metastatic pulmonary tumors were fed a daily diet containing EPA or EPB at doses of 8, 20, or 50 mg/kg. Results showed that the proliferation of pulmonary sarcoma lesions was lower in the groups fed EPS. In addition, the numbers of total T cells, CD4+ cells, CD8+ cells, and macrophages significantly increased in EPS-fed mice compared with the negative control group. The antitumor and immunomodulating effects observed in the EPB-fed groups were higher than those of EPA-fed groups. These results demonstrate the ability of EPSs of C. maxima to inhibit tumor cells while enhancing immune response.


Articles with similar content:

Immunomodulatory Activities of Polysaccharides from White Button Mushroom, Agaricus bisporus (Agaricomycetes), Fruiting Bodies and Cultured Mycelia in Healthy and Immunosuppressed Mice
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 1
Dinghe Wang, Ling Su, Yu Li, Dandan Zheng, Qi Wang, Yang Liu
Immunomodulation and Antitumor Activity of a Mushroom Product, Proflamin, Isolated from Flammulina velutipes (W. Curt.: Fr.) Singer (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Tetsuro Ikekawa, Hirofumi Maruyama
Inhibitory Effects of Extracts from Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) on Immediate Type Allergy Induced Compound 48/80 in ICR Mice
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Sachiko Kawakami, Yasushi Chida, Masashi Mizuno
Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 8
Edwin A. Higuita, Andrea M. Cano, Sandra Lorena Duque Henao, Sergio A. Urrego
High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 1
Raffaello Di Bernardi, Rosalia Rubel, Jose Hermenio Cavalcante Lima Filho, Carlos Ricardo Soccol, Luiz Claudio Fernandes, Andrea N. Moreno, Fan Leifa, Herta Stutz Dalla Santa, Bonald Cavalcante Figueiredo