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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i1.30
pages 13-21

Development and Validation of an LC-MS/MS Method for the Quantification of Agaritine in Mushrooms

Simon Merdivan
Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-Universitat, Greifswald, Germany
Christoph Willke
Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-Universitat, Greifswald, Germany
Ulrike Lindequist
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

RÉSUMÉ

Agaritine, an aromatic hydrazine, is found as a secondary metabolite in mushroom species. It is among others suspected to exhibit genotoxic activity. This publication describes the validation of a method for the quantification of agaritine in mushrooms (i.e., extraction and purification by solid phase extraction) and measurement by liquid chromatography with tandem mass spectrometry detection in positive ionization mode. The results show this method to be selective, accurate, and precise. This method could be used for the quality control of pharmaceutical preparations containing mushrooms.


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