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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i1.60
pages 49-57

Activity of Extracts from Submerged Cultured Mycelium of Winter Mushroom, Flammulina velutipes (Agaricomycetes), on the Immune System In Vitro

Svetlana Kashina
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México
Lerida Liss Flores Villavicencio
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México
Silvio Zaina
Division de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, Leon, Guanajuato, México
Marco Balleza Ordaz
Division de Ingenierias, Departamento de Fisica Médica, Universidad de Guanajuato, Leon, Guanajuato, México
Gloria Barbosa Sabanero
Division de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, Leon, Guanajuato, México
Victor Tsutsumi Fujiyoshi
Centro de Investigacion y de Estudios Avanzados, Departamento de Infectomica y Patogénesis Molecular, Unidad Zacatenco, México, México
Myrna Sabanero Lopez
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México

RÉSUMÉ

Extracts from submerged cultured mycelium of two strains of Flammulina velutipes, a popular culinary mushroom, were obtained by ultrasound and tested in vitro to determine their activity in innate immunity (monocytes/ macrophages). In addition, polyclonal antibodies against the extracts were produced. Both extracts have similar glycoproteins that contain mannose and glucose but have different glycoproteins with galactoseamine units. Two novel immunogenic glycoproteins with molecular weights of 32 and 25 kDa have been revealed. It is thought that these proteins are produced only by submerged cultured mycelium. Both extracts show immune-enhancing activity based on the significant modification of various parameters such as cytokine production, phagocytosis, and reactive oxygen species production.


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