Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i11.50
pages 1055-1060

Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes)

Mingxing Wang
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Tetsuya Konishi
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Yang Gao
Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Duoduo Xu
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Qipin Gao
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China

RÉSUMÉ

Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H. erinaceus exhibits various pharmacological properties, such as anti-cancer, immunomodulation, anti-dementia, and anti-gastric ulcer effects. The extracts of the fruiting body of H. erinaceus demonstrate anti-gastritis activity. However, the active principle in the extract, as well as the mechanism to treat gastric ulcers, remains uncertain. The current study aims to identify the active component, with anti-gastric ulcer function, from the extracts of the H. erinaceus mycelium culture. In the experiment, anti-gastric ulcer activity was evaluated using an ethanol-induced ulcer model in mice and with an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay using MC cell lines. The results suggest that the polysaccharide fraction can significantly decrease the ulcerated area compared with the control group and the effect is fairly dose dependent, irrespective of animal or cell experiments. These results indicate that the polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.


Articles with similar content:

Ethanolic Extract of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), Alleviates Metabolic Syndrome in Diet-Induced Obese Mice
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Changhui Zhao, Quanbo Chi, Kunlun Huang, Pengfei Shi, Guoyi Wang, Yao Sheng, Wentao Xu
Antitumor Effect of By-1 from Spent Broth from Submerged Cultures of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Higher Basidiomycetes), on A549 Adenocarcinoma Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 3
Jing-Song Zhang, Wei Jia, Wenhan Wang, Hua Fan, Hai-Rui Yang, Xiang-Li Zhao, Ya-Ping Zhang, Li-Yuan Wang, He-Nan Zhang
Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 4
Gokhan Bayramoglu, Leonardus Johannes Lambertus Donatus Van Griensven, Mustafa Yamac, Hakan Senturk, Gungor Kanbak, Aysegul Oglakci, Melih Zeytinoglu, Kazim Kartkaya
Diverse Effects of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Combination with Tamoxifen Citrate and Doxorubicin in MCF-7 Breast Cancer Cells
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 6
Sevcan Atay, Erbil Kalmis, Handan Ak, Husniye Kayalar, Hikmet Hakan Aydin
Immunomodulatory Effects of the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes)-Based Health Food Product in Mice
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 9
Chin-Chung Lin, K. J. Senthil Kumar, Chiu-Ping Lo, Sheng-Yang Wang, Jong-Tar Kuo, Yun-Yu Chen, Yu-Hsing Lin