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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Aqueous Extracts of Cordyceps militaris (Ascomycetes) Lower the Levels of Plasma Glucose by Activating the Cholinergic Nerve in Streptozotocin-Induced Diabetic Rats

Volume 15, Numéro 3, 2013, pp. 277-286
DOI: 10.1615/IntJMedMushr.v15.i3.50
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RÉSUMÉ

In our previous research, Cordyceps militaris (CM) had a hypoglycemic effect in normal rats. In this study we wanted to elucidate whether CM also had an effect on diabetic rats. Twelve rats with streptozotocin-induced diabetes were separated randomly into 2 groups. First, aqueous extracts of CM 10 mg/kg (CM group) or saline (control group) was fed to the rats; then the plasma glucose levels were assayed. Second, the signaling proteins IRS-1 and GLUT-4 collected from the muscle were detected. Finally, another 2 groups of rats were injected with atropine 0.1 mg/kg intraperitoneally just before the CM/saline feeding, and the assays mentioned above were repeated. Blood glucose decreased 7.2% in the CM group but only 1.5% in the control group (P < 0.05). The IRS-1 signal was 2.9-fold higher than actin in the CM group but only 0.8-fold higher in the control group (P < 0.005). In GLUT-4 signal, the difference was 1.7- vs. 0.6-fold, respectively, compared with actin (P < 0.05). However, atropine injection made CM-induced hypoglycemia or elevation of IRS-1 and GLUT-4 not significant. In conclusion, CM had a hypoglycemic effect in diabetic rats and atropine blocked it. Therefore, the cholinergic activation also was considered to be involved in the hypoglycemic effect of CM in rats with streptozotocin-induced diabetes.

CITÉ PAR
  1. Liu Xiaojuan, Huang Yicheng, Chen Yunjiao, Cao Yong, Partial structural characterization, as well as immunomodulatory and anti-aging activities of CP2-c2-s2 polysaccharide from Cordyceps militaris, RSC Adv., 6, 106, 2016. Crossref

  2. Liu Hong, Cao Diyong, Liu Hua, Liu Xinghai, Mai Wenli, Lan Haitao, Huo Wen, Zheng Qian, The Herbal Medicine Cordyceps sinensis Protects Pancreatic Beta Cells from Streptozotocin-Induced Endoplasmic Reticulum Stress, Canadian Journal of Diabetes, 40, 4, 2016. Crossref

  3. Mingyi Yang, Belwal Tarun, Devkota Hari Prasad, Li Li, Luo Zisheng, Trends of utilizing mushroom polysaccharides (MPs) as potent nutraceutical components in food and medicine: A comprehensive review, Trends in Food Science & Technology, 92, 2019. Crossref

  4. Sun Jingbo, Xu Jian, Wang Shan, Hou Zhidong, Lu Xuechun, An Liping, Du Peige, A new cerebroside from cordyceps militaris with anti-PTP1B activity, Fitoterapia, 138, 2019. Crossref

  5. Turło Jadwiga, The biotechnology of higher fungi - current state and perspectives, Folia Biologica et Oecologica, 10, 2014. Crossref

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