Abonnement à la biblothèque: Guest
International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models

Volume 13, Numéro 5, 2011, pp. 427-440
DOI: 10.1615/IntJMedMushr.v13.i5.20
Get accessGet access

RÉSUMÉ

Previously, we reported the in vitro anticancer and immunomodulatory effect of a protein fraction designated as Cibacron blue affinity purified protein (CBAEP) obtained from the culinary-medicinal oyster mushroom, Pleurotus ostreatus. In the present study, we investigated the in vivo antitumor potential of CBAEP in different tumor-bearing mice models and studied the detailed mechanism of tumor regression in Dalton lymphoma (DL)-bearing mice. The lethal dose (LD50) of CBAEP was found to be 55 mg/kg body weight and sublethal doses (5 mg/kg and 10 mg/kg body weight) showed a prolonged tumor survival time in DL, Sarcoma-180, and B16F0 melanoma tumor-bearing mice. Further, CBAEP reduced about 35.68 and 51.43% DL cell growth in 5 and 10 mg/kg body weight, respectively. The in vivo CBAEP treatment showed an apoptotic feature as demonstrated in morphological study and sub-G0/G1 population in cell cycle and Western blot of DL cells. CBAEP also activated immunosuppression condition in DL tumor-bearing host. It also stimulated immune cells in the presence of nonspecific immunostunulator (LPS and ConA) ex vivo as well as enhanced Th1 response with production of TNF-α, IFN-γ, and IL-2. Moreover, it activated tumor-associated macrophages and NK cells. The present findings revealed the potent antitumor property of CBAEP, which might help in developing a new anticancer drug.

CITÉ PAR
  1. Raman Jegadeesh, Reddy G. Rajasekhar, Lakshmanan Hariprasath, Selvaraj Veerapandian, Gajendran Babu, Nanjian Raaman, Chinnasamy Arulvasu, Sabaratnam Vikineswary, Mycosynthesis and characterization of silver nanoparticles from Pleurotus djamor var. roseus and their in vitro cytotoxicity effect on PC3 cells, Process Biochemistry, 50, 1, 2015. Crossref

  2. Pineda-Alegría Jesús Antonio, Sánchez-Vázquez José Ernesto, González-Cortazar Manases, Zamilpa Alejandro, López-Arellano María Eugenia, Cuevas-Padilla Edgar Josúe, Mendoza-de-Gives Pedro, Aguilar-Marcelino Liliana, The Edible MushroomPleurotus djamorProduces Metabolites with Lethal Activity Against the Parasitic NematodeHaemonchus contortus, Journal of Medicinal Food, 20, 12, 2017. Crossref

  3. Haque Md. Anwarul, Islam Md. Anwar Ul, Pleurotus highking Mushroom Induces Apoptosis by Altering the Balance of Proapoptotic and Antiapoptotic Genes in Breast Cancer Cells and Inhibits Tumor Sphere Formation, Medicina, 55, 11, 2019. Crossref

  4. Chaitanya MVNL, Jose Asha, Ramalingam P, Mandal SC, Kumar PNarendra, Multi-targeting cytotoxic drug leads from mushrooms, Asian Pacific Journal of Tropical Medicine, 12, 12, 2019. Crossref

  5. Angelini Paola, Pellegrino Roberto Maria, Tirillini Bruno, Flores Giancarlo Angeles, Alabed Husam B. R., Ianni Federica, Blasi Francesca, Cossignani Lina, Venanzoni Roberto, Orlando Giustino, Menghini Luigi, Ferrante Claudio, Metabolomic Profiling and Biological Activities of Pleurotus columbinus Quél. Cultivated on Different Agri-Food Byproducts, Antibiotics, 10, 10, 2021. Crossref

  6. Monticolo Francesco, Chiusano Maria Luisa, Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods, Cancers, 13, 16, 2021. Crossref

1559 Vues d'articles 70 Téléchargements d'articles Métrique
1559 VUES 70 TÉLÉCHARGEMENTS 6 Crossref CITATIONS Google
Scholar
CITATIONS

Articles avec un contenu similaire:

Macrophages Stimulated by Polysaccharide Purified from Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae) Enhance mRNA Expression of Th1 Cytokine Including IL-12 and 18 International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Nobuhide Fujitake, Sachiko Kawakami, Masashi Mizuno
The Medicinal Benefits of Lentinan (β-1, 3-D glucan) from Lentinus edodes (Berk.) Singer (Shiitake Mushroom) Through Oral Administration International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Mah-Lee Ng, Ann-Teck Yap
Immunopotentiating Properties of Lentinan (1®3)-b-D-glucan Extracted from Culinary–Medicinal Shiitake Mushroom Lentinus edodes (Berk.) Singer (Agaric International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Mah-Lee Ng, Ann-Teck Yap
Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine–Induced Toxicity in Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Abul Vafa, Rahat Ali, Sarwat Sultana, Aisha Siddiqi, Alpashree, Preeti Barnwal, Syed Kazim Hasan, Shekh Mohammad Afzal, Johirul Islam
Immune-Stimulating Effects of Mycoleptodonoides aitchisonii (Agaricomycetes) Water Extract via TNF-α and IFN-γ International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Hong De Xu, Deuk-Sil Oh, Seung-Kil Lim, Seung-Sik Cho, Dae-Hun Park, Soon-Young Lee
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain