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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019031175
pages 683-691

Wound Healing Activity of a Skin Substitute from Residues of Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes) Cultivation

Hui Xu
shenyang pharmaceutical university; Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Liangyun Liu
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Chongjiang Cao
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Weisheng Lu
State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, P.R. China
Zhenhan Zhu
Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, P.R. China
Zijun Guo
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Min Li
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Xing Wang
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Dechun Huang
Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, P.R. China
Suilou Wang
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China
Shujie Cheng
Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, China Pharmaceutical University, Nanjing, P.R. China

RÉSUMÉ

A skin substitute TG05 obtained from residues of the culinary-medicinal mushroom Flammulina velutipes cultivation process was developed in this study for the first time. Pre-column derivatization high-performance liquid chromatography fingerprints analysis revealed that TG05 was composed of water-insoluble fibers containing xylose (57%), glucose (19.5%), and arabinose (16.3%) as major monomers. Porous and opaque structure of TG05 was demonstrated by scanning electron microscopy. Animal experiments conducted on mice and rats indicated that TG05 notably accelerated the wound-healing process. In addition, TG05 induced proliferation and migration of human keratinocytes time- and dose-dependently. Taken together, the skin substitute TG05 with new structure promotes wound healing in vitro and in vivo. This study provided a novel method to produce functional biomaterial from abundant and low-cost agricultural residues generated during edible mushroom cultivation.

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