Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
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Antioxidative and Inhibitory Effects of the Fruiting Body of Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), on LDL Oxidation and HMG-CoA Reductase Activity
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RÉSUMÉ
Amauroderma rugosum fruiting bodies possess excellent cardiovascular benefits, including antioxidative, antihyperlipidemic, antihypertensive, antiinflammatory, anti-platelet aggregation, and antithrombotic effects. In this article, we describe our investigations of the in vitro antioxidant activity and in vitro antiatherosclerotic potential through inhibitory effects on low-density lipoprotein (LDL), LDL peroxidation, and 3-hydroxy3-methylglutaryl-coenzyme A (HMG-CoA) reductase catalytic activity using various fruiting body extracts partitioned with an organic solvent. Among 5 extracts/fractions tested, the semipolar ethyl acetate (EA) fraction demonstrated good antioxidant capacity based on total phenolic content, 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, ferrous ion-chelating ability, cupric ion-reducing antioxidant capacity, and lipid peroxidation assays. The EA fraction also showed the strongest inhibitory effect on Cu2+-induced LDL oxidation via thiobarbituric acid reactive substances formation and HMG-CoA reductase activity. Chemical analysis conjointly identified 10 phenolic compounds (4 benzoic acid derivatives, 3 flavonoids, 1 cinnamic acid, 1 hexahydroxydiphenic acid dilactone, and 1 xanthone derivative), some of which play pivotal roles in arresting the physiopathogenesis of atherosclerosis, thereby attenuating the risk of cardiovascular events occurring.
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Félix Rafael, Valentão Patrícia, Andrade Paula B., Félix Carina, Novais Sara C., Lemos Marco F. L., Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage, Antioxidants, 9, 3, 2020. Crossref
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Lin Weiping, Shi Yanhua, Jia Guangtao, Sun Hengyi, Sun Tongyi, Hou Dianhai, Genome sequencing and annotation and phylogenomic analysis of the medicinal mushroom Amauroderma rugosum, a traditional medicinal species in the family Ganodermataceae, Mycologia, 113, 2, 2021. Crossref
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Li Jingjing, Cheng Yanfen, Li Renkai, Wu Xiaoping, Zheng Chengwen, Shiu Polly Ho-Ting, Chan Jacqueline Cho-Ki, Rangsinth Panthakarn, Liu Conghui, Leung Susan Wai-Sum, Lee Simon Ming-Yuen, Zhang Chen, Fu Chaomei, Zhang Jinming, Cheung Timothy Man-Yau, Leung George Pak-Heng, Liang Shao, Protective Effects of Amauroderma rugosum on Doxorubicin-Induced Cardiotoxicity through Suppressing Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Activating Akt/mTOR and Nrf2/HO-1 Signaling Pathways, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref
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Mai Yanzhen, Xu Siyuan, Shen Ru, Feng Bairu, He Hong, Xu Yifei, Gastroprotective effects of water extract of domesticated Amauroderma rugosum against several gastric ulcer models in rats, Pharmaceutical Biology, 60, 1, 2022. Crossref
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Zheng Cheng‐Wen, Cheung Timothy Man‐Yau, Leung George Pak‐Heng, A review of the phytochemical and pharmacological properties of Amauroderma rugosum , The Kaohsiung Journal of Medical Sciences, 38, 6, 2022. Crossref
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Theofanous Thekla, Kourti Malamati, Abrogating Oxidative Stress as a Therapeutic Strategy Against Parkinson’s Disease: A Mini Review of the Recent Advances on Natural Therapeutic Antioxidant and Neuroprotective Agents, Medicinal Chemistry, 18, 7, 2022. Crossref
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Shiu Polly Ho-Ting, Li Jingjing, Zheng Chengwen, Rangsinth Panthakarn, Li Renkai, Cheung Queenie Tze-Lam, Lau Angel Heng-Yee, Chan Jacqueline Cho-Ki, Kwan Yiu-Wa, Cheung Timothy Man-Yau, Leung George Pak-Heng, Amauroderma rugosum Extract Suppresses Inflammatory Responses in Tumor Necrosis Factor Alpha/Interferon Gamma-Induced HaCaT Keratinocytes, Molecules, 27, 19, 2022. Crossref