Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Toxicity and Antitumor Activity of a Crude Extract from Lepista inversa (Scop.:Fr.) Pat. (Agaricomycetideae): A Preliminary Study
Get access
RÉSUMÉ
The antitumor activity of a crude extract of the mushroom Lepista inversa (Scop.: Fr.) Pat. Was studied against intraperitoneally transplanted lymphocytic leukemia (L1210) and intramuscularly transplanted Lewis lung carcinoma (3LL) in mice. The 50% lethal dose was determined to be about 500 mg/kg for an i.p. administration of the extract. Intraperitoneal administration of 75 mg/kg of body weight/day of the extract increased the lifespan of L1210 and 3LL tumor-bearing mice by 50% and 14%, respectively, with respect to the control group. The antileukemic activity against the L1210 model in mice was considered to be significant.
-
Fortin Hélène, Tomasi Sophie, Delcros Jean-Guy, Bansard Jean-Yves, Boustie Joël, In Vivo Antitumor Activity of Clitocine, an Exocyclic Amino Nucleoside Isolated fromLepista inversa, ChemMedChem, 1, 2, 2006. Crossref
-
De Silva Dilani D., Rapior Sylvie, Fons Françoise, Bahkali Ali H., Hyde Kevin D., Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action, Fungal Diversity, 55, 1, 2012. Crossref
-
Borchers Andrea T., Keen Carl L., Gershwin M. Eric, Mushrooms, Tumors, and Immunity: An Update, Experimental Biology and Medicine, 229, 5, 2004. Crossref
-
Murakawa Kentaro, Fukunaga Kenji, Tanouchi Masatoshi, Hosokawa Masashi, Hossain Zakir, Takahashi Koretaro, Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator, Journal of Oleo Science, 56, 4, 2007. Crossref