Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v5.i1.30
6 pages

Toxicity and Antitumor Activity of a Crude Extract from Lepista inversa (Scop.:Fr.) Pat. (Agaricomycetideae): A Preliminary Study

Carine Bezivin
Laboratoire de Pharmacognosie et Mycologie, Faculte de Pharmacie, UPRES EA 2234, 2 Av. du Pr. L. Bernard, 35043 Rennes Cedex, France
Jean-Guy Delcros
Groupe de Recherche en Therapeutique Anticancereuse, Faculte de Medecine, CNRS FRE 2261, 2 Av. du Pr. L. Bernard, 35043 Rennes Cedex, France
Helene Fortin
Laboratoire de Pharmacognosie et Mycologie, Faculte de Pharmacie, UPRES EA 2234, 2 Av. du Pr. L. Bernard, 35043 Rennes Cedex, France
Maryvonne Amoros
Laboratoire de Pharmacognosie et Mycologie, Faculte de Pharmacie, UPRES EA 2234, 2 Av. du Pr. L. Bernard, 35043 Rennes Cedex, France
Joel Boustie
Laboratoire de Pharmacognosie et Mycologie, Faculte de Pharmacie, UPRES EA 2234, 2 Av. du Pr. L. Bernard, 35043 Rennes Cedex, France

RÉSUMÉ

The antitumor activity of a crude extract of the mushroom Lepista inversa (Scop.: Fr.) Pat. Was studied against intraperitoneally transplanted lymphocytic leukemia (L1210) and intramuscularly transplanted Lewis lung carcinoma (3LL) in mice. The 50% lethal dose was determined to be about 500 mg/kg for an i.p. administration of the extract. Intraperitoneal administration of 75 mg/kg of body weight/day of the extract increased the lifespan of L1210 and 3LL tumor-bearing mice by 50% and 14%, respectively, with respect to the control group. The antileukemic activity against the L1210 model in mice was considered to be significant.


Articles with similar content:

Anti-Tumor Activity of Aloe vera Against DMBA/Croton Oil-Induced Skin Papillomagenesis in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
Pradeep Kumar Goyal, Geeta Chaudhary, M. R. Saini
Immunomodulation and Antitumor Activity of a Mushroom Product, Proflamin, Isolated from Flammulina velutipes (W. Curt.: Fr.) Singer (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Tetsuro Ikekawa, Hirofumi Maruyama
Antitumor Activity and Hematopoietic Response of a b-Glucan Extracted from an Edible and Medicinal Mushroom Sparassis crispa Wulf.: Fr. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 1
Shinya Masuzawa, Yoshiyuki Adachi, Noriko N. Miura, Toshiro Yadomae, Mitsuhiro Nakajima, Naohito Ohno, Toshie Harada
The Antitumor Activity of Ganoderma lucidum (Curt.:Fr.)P. Karst. (Ling Zhi) (Aphyllophoromycetideae) Polysaccharides Is Related to Tumor Necrosis Factor-α and Interferon-γ
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 3
Zhi-Bin Lin, Qun-Hao Zhang
Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 5
Mohitosh Mandal, Birendra Behera, Sujit Kumar Bhutia, Swatilekha Maiti, Tapas K Maiti, Sanjaya Kumar Mallick