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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Submerged Cultured Mycelium Extracts of Higher Basidiomycetes Mushrooms Selectively Inhibit Proliferation and Induce Differentiation of K562 Human Chronic Myelogenous Leukemia Cells

Volume 5, Numéro 3, 2003, 16 pages
DOI: 10.1615/InterJMedicMush.v5.i3.40
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RÉSUMÉ

Human chronic myelogenous leukemia (CML) is a malignancy of pluripotent hematopoietic cells characterized by a distinctive cytogenetic abnormality known as the Philadelphia (Ph) chromosome, which results in the creation of a p210Bcr–Abl fusion protein with increased tyrosine kinase activity. Forty-two species of Higher Basidiomycetes mushrooms were cultivated as pure cultures in submerged conditions, and dry mycelium was used to prepare 168 different crude extracts. The crude extracts were used to evaluate antiproliferative activity against a number of cancer cell lines, including K562 (human chronic myelogenous leukemia cell line), Jurkat (human T lymphoblast cells), HT29 (human colon adenocarcinoma cells), MH3924A (rat Morris hepatoma), and ABAE (adult bovine aortic endothelial cells) using XTT proliferation assay. Forty-four crude extracts with antiproliferative effect against K562 cells were selected, and eight mycelium extracts were K562-selective compared with MH3924A, HT29, ABAE, and Jurkat cells. Growth inhibition against K562 ranged from 51% to 78% compared with solvent-treated samples. Most crude extracts exhibited a complete or partial cytostatic effect against K562 cells. The anti-proliferative effect observed by the selected crude extracts was attributed to the induction of an apoptosis pathway as determined by Apostain ELISA assay and by monitoring PARP cleavage. It is interesting that crude extract MH428 was the most active extract in inducing apoptosis of K562 cells. In addition, expression levels of p210Bcr–Abl were affected by the presence of the selected crude extracts. Our data revealed a significant inhibition of p210Bcr–Abl expression by MH428 extract, a moderate effect by MH17, and minor changes by the other extracts. Furthermore, mycelium crude extracts were active in inducing erythroid differentiation in K562 cells. Crude extracts Meth178, MH17, and MH428 showed significant ability to induce hemoglobin production in K562 cells, as indicative of erythroid differentiation. The results obtained support the potential use of the crude mycelium extracts for the treatment of CML and beta-globin disorders.

CITÉ PAR
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  2. Morris Humberto J., Lebeque Yamila, Fontaine Roberto, Bermúdez Rosa C., Llauradó Gabriel, Marcos Jane, A note on thein vitromacrophage-stimulating activity of water-soluble extracts from mycelium ofPleurotusspp., Food and Agricultural Immunology, 18, 1, 2007. Crossref

  3. Sun Jian-guo, Li Hua, Li Xia, Zeng Xueli, Wu Ping, Fung Kwok-Pui, Liu Fei-yan, Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo, Apoptosis, 19, 5, 2014. Crossref

  4. Wang Lei, Hou Yunhua, Determination of Trace Elements in Anti-influenza Virus Mushrooms, Biological Trace Element Research, 143, 3, 2011. Crossref

  5. Najajreh Yousef, Khamaisie Hazem, Ruimi Nili, Khatib Soliman, Katzhendler Joshua, Ruthardt Martin, Mahajna Jamal, Oleylamine-carbonyl-valinol inhibits auto-phosphorylation activity of native and T315I mutated Bcr-Abl, and exhibits selectivity towards oncogenic Bcr-Abl in SupB15 ALL cell lines, Molecular Biology Reports, 40, 3, 2013. Crossref

  6. Ruimi Nili, Petrova Roumyana D., Agbaria Riad, Sussan Sherbel, Wasser Solomon P., Reznick Abraham Z., Mahajna Jamal, Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms, Molecular Biology Reports, 37, 8, 2010. Crossref

  7. Dotan Nesly, Wasser Solomon P., Mahajna Jamal, Inhibition of the Androgen Receptor Activity by Coprinus comatus Substances, Nutrition and Cancer, 63, 8, 2011. Crossref

  8. Lin Jiun-Tsai, Liu Wen-Hsiung, ο-Orsellinaldehyde from the Submerged Culture of the Edible Mushroom Grifola frondosa Exhibits Selective Cytotoxic Effect Against Hep 3B Cells Through Apoptosis, Journal of Agricultural and Food Chemistry, 54, 20, 2006. Crossref

  9. Sharvit Lital, Bar-Shalom Rinat, Azzam Naiel, Yechiel Yaniv, Wasser Solomon, Fares Fuad, Cyathus striatus Extract Induces Apoptosis in Human Pancreatic Cancer Cells and Inhibits Xenograft Tumor Growth In Vivo, Cancers, 13, 9, 2021. Crossref

  10. Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref

  11. Fares Fuad, Khatib Soliman, Vaya Jacob, Sharvit Lital, Eizenberg Einav, Wasser Solomon, Striatal Isolated from Cyathus striatus Extracts Induces Apoptosis in Human Pancreatic Cancer Cells, Molecules, 27, 9, 2022. Crossref

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