Abonnement à la biblothèque: Guest
International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Peroral Effect on Tumor Progression of Soluble β-(1, 6)-Glucans Prepared by Acid Treatment from Agaricus blazei Murr. (Agaricaceae, Higher Basidiomycetes)

Volume 2, Numéro 1, 2000, 7 pages
DOI: 10.1615/IntJMedMushr.v2.i1.40
Get accessGet access

RÉSUMÉ

Orally deliverable anticancer agents are becoming increasingly important in cost reduction of regimens for disorders that require protracted treatment and for patients' increasing preference and improved quality of life. The present study describes a simple procedure for the development of orally formulated anticancer agents of natural origin. The tumoricidal effects of natural products and purified extracts have previously been examined in single-grafted Meth-A tumor-bearing BALB/c mice by intratumoral injection of extracts from Agaricus blazei. Intratumoral administration of an ammonium oxalate-soluble/water- and ethanol-insoluble fraction 3, resulted in marked tumor regression, but continuous oral administration of feed containing fraction 3 from day 4 or 18 prior to tumor inoculation to day 21 after inoculation did not result in tumor regression. Intratumoral administration of fractions prepared by acid hydrolysis of either fraction 3 (ATF) or whole organisms (wATF) resulted in tumor regression almost identical to that seen using fraction 3. Oral administration of either soluble ATF or wATF also resulted in significant suppression of the progressive tumor, wATF being more active than ATF. ATF and wATF are composed predominantly of β-(1, 6)-glucans with apparent molecular masses of 10 kDa, with some unknown metabolite contamination (<20%). These results demonstrate that simple acid treatment of whole natural basidiomycetous products consisting mainly of β-(1, 6)-glucans can offer a valid approach to the development of anticancer agents that are orally effective, thus eliminating the need for multiple purification steps.

CITÉ PAR
  1. Gu YeunHwa, Fujimiya Yoshiaki, Itokawa Yuka, Oshima Masami, Choi Jung-Sook, Miura Toshihiro, Ishida Torao, Tumoricidal Effects of β-Glucans: Mechanisms Include Both Antioxidant Activity Plus Enhanced Systemic and Topical Immunity, Nutrition and Cancer, 60, 5, 2008. Crossref

Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain