Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Activation of Hippocampal Pyramidal Neurons N-Methyl-D-Aspartate Receptors and M-cholinoreceptors During the Application of Amanita (Pers.: Fr.) Hook. Species Extracts
RÉSUMÉ
Effects of synaptic transmission antagonists on the spike responses of 15 pyramidal neurons of the CA1 region of rat hippocampus during the application of extracts from Amanita species were studied. Antagonists of M-cholinoreceptors (atropine), N-methyl-D-aspartic (NMDA) receptors [amantadine, ketamine, DL-2-amino-4-phosphonobutyric acid (AP-4)], and γ-aminobutyric acid-A (GABAA) receptors (bicuculline) were applied. Usually, the application of extracts from A. muscaria, A. pantherina, and A. rubescens caused a long excitation of neurons, which resulted from of M-cholinoreceptors and NMDA receptors activation. Some neurons were excited due to the activation of only one of the indicated receptor types, which most probably reflected peculiarities of the cell's afferent connections. It is suggested that the excitation was caused by muscarine and (or) ibotenic acid present in A. muscaria and A. pantherina extracts. A short neuron excitation blocked by atropine was observed during the application of A. citrina extracts as well. Some neurons showed inhibition during the application of A. rubescens extract that was blocked by atropine. However, a long inhibition caused by A. citrina extract application was not blocked either by atropine or bicuculline. Additional biochemical studies are required to determine agonists of muscarine in A. rubescens and A. citrina and agonists of glutamate in A. rubescens.