Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.211 Facteur d'impact sur 5 ans: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.70
6 pages

Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice

Zhi-Bin Lin
Department of Pharmacology, School of Basic Medical Sciences, Beijing University, Beijing 100083, P. R. China
Ming-Yu Wang
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qiang Liu
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qing-Ming Che
Department of Traditional Chinese Medicine Drugs, College of Pharmacy, Peking University, Beijing, 100083. People's Republic of China

RÉSUMÉ

The effect of total triterpenoids extract isolated from Ganoderma lucidum (Curt.: Fr.) P. Karst. (GT) on two different experimental liver injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-Gal) was studied in mice. The liver triglycerides (TG), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and serum alanine aminotransferase (ALT) were measured. The histopathological changes in the liver were assayed in mice. The results were as follows: GT (80 mg/kg) and GT2 (10, 20, 40 mg/ kg), as malotilate, were shown to significantly inhibit the increase of serum ALT and liver TG levels in the models. GT could antagonize the decrease of SOD activity and liver GSH content and inhibit the increase of the liver MDA content in the liver-injury mice induced by CCl4 or D-Gal. Also, it could improve the histopathological changes of liver injury. The results demonstrate that total triterpenoids isolated from G. lucidum have powerful protective effects against liver damage induced by CCl4 or D-Gal. Their hepato-protective effects were perhaps related to the ability to promote the activity of scavenging enzymes for hepatic free radicals in mice, and thus to raise the ability of antioxidation in mice.


Articles with similar content:

Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Jyun-Han Chen, Lean Teik Ng, Huey-Jiun Ko
Ameliorative Effect of Green Tea Catechin Against Cadmium Chloride−Induced Testicular Toxicity in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
Priyanka Sharma, Pradeep Kumar Goyal
Protective Effect of Diphenylmethyl Selenocyanate Against Carbon Tetrachloride-Induced Hepatotoxicity In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.23, 2004, issue 4
Rajat Kumar Das, Sudin Bhattacharya, Sukta Das
Medicinal Mushroom Cracked-Cap Polypore, Phellinus rimosus (Higher Basidiomycetes) Attenuates Acute Ethanol-Induced Lipid Peroxidation in Mice
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan
The Hepatoprotective Effect of Clidemia hirta against Carbon Tetrachloride (CCl4)−Induced Oxidative Stress and Hepatic Damage in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 4
Mohammad Iqbal, Nurul Amzar