Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Analysis of the Titer and Reactivity of Antibody/ies Against Fungal Cell Wall β-Glucans in Human Sera
RÉSUMÉ
The aim of this work was to characterize an antibody response to β-glucan (BG), a major component of the fungal cell wall, at each isotype in human sera. The titer and reactivity of the anti-human BG antibody were examined using enzyme-linked immunosorbant assay plates coated with Candida soluble cell wall β-glucan as a standard antigen. The antibody was detected using anti-human immunoglobulin (Ig) G, IgM, and IgA. Its major class was IgG in all subjects. The antibody titer varied significantly. The anti-BG antibody showed greater reactivity to β-glucans derived from pathogenic fungi than monoglycosyl-branched β-glucans derived from mycelia culture medium. In addition, it was suggested that the anti-BG IgM antibody was bound relatively strongly to the β1,3-glucan backbone and the anti-BG IgG antibody to β1,6-glucan. The anti-BG antibody plays a variety of roles, according to class, in the host's response to fungi. We propose a new index of human response to β-glucan that effects the understanding of the response to β-glucan in humans.
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Chan Anissa S. H., Jonas Adria Bykowski, Qiu Xiaohong, Ottoson Nadine R., Walsh Richard M., Gorden Keith B, Harrison Ben, Maimonis Peter J., Leonardo Steven M., Ertelt Kathleen E., Danielson Michael E., Michel Kyle S., Nelson Mariana, Graff Jeremy R., Patchen Myra L., Bose Nandita, Lee Bok-Luel, Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation, PLOS ONE, 11, 11, 2016. Crossref
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Ishibashi Ken-ichi, Nishioka Machiko, Onaka Nobuteru, Takahashi Madoka, Yamanaka Daisuke, Adachi Yoshiyuki, Ohno Naohito, Effects of Euglena gracilis EOD-1 Ingestion on Salivary IgA Reactivity and Health-Related Quality of Life in Humans, Nutrients, 11, 5, 2019. Crossref
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Bose Nandita, Ottoson Nadine R., Qiu Xiaohong, Harrison Ben, Lowe Jamie R., Uhlik Mark T., Rathmann Blaine T., Kangas Takashi O., Jordan Lindsay R., Ertelt Kathleen E., Jonas Adria Bykowski, Walsh Richard M., Chan Anissa S. H., Fulton Ross B., Leonardo Steven M., Fraser Kathryn A., Gorden Keith B., Matson Mark A., Graff Jeremy R., Huhn Richard D., Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers, The Journal of Immunology, 202, 10, 2019. Crossref
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Ohno Naohito, Fungal Polysaccharides, in Comprehensive Glycoscience, 2021. Crossref
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Ohno Naohito, Fungal Beta-glucans: Structure and Effect on Host Immune Responses, YAKUGAKU ZASSHI, 141, 5, 2021. Crossref
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Wich Melissa, Greim Stephanie, Ferreira-Gomes Marta, Krüger Thomas, Kniemeyer Olaf, Brakhage Axel A., Jacobsen Ilse D., Hube Bernhard, Jungnickel Berit, Functionality of the human antibody response to Candida albicans, Virulence, 12, 1, 2021. Crossref