Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Positive Effect of Selenium on the Immune Regulation Activity of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae), Proteins In Vitro
RÉSUMÉ
The medicinal mushroom Ganoderma lucidum (Ling Zhi or Reishi) has many biological functions, including immunity-regulation activity. Selenium (Se) is an essential trace element in animals. Our previous studies showed that G. lucidum canbiotransform20%-30% of inorganic Se from substrate. Moreover, the Se was biotransformed preferentially in forms of Se-containing proteins. Therefore, it is interesting to know how selenium influences the activity of the proteins in G. lucidum. In the present study, the effects of crude proteins (SeGLPr) from Se-enriched G. lucidum (Se-G. lucidum) and a novel protein Se-GL-P purified from Se-G. lucidum on the multiplication of T- and B-lymphocyte cells and the activity of NK cells were determined in vitro, respectively. The biological activities of the two samples were compared with four other samples, including Na2SeO3, [Na2SeO3+BSA], crude proteins from regular G. lucidum (GLPr), and [Na2SeO3+GLPr], under the same conditions. Results showed that, at the same protein and Se concentration, Se-GL-P exhibited the strongest activity among six samples in promoting the multiplication of T and B cells as well as the killer activity of NK cells with a protein concentration ranging from 20 to 2000 μg/mL. Moreover, GLPr has shown immunity-regulation activity, and the incorporation of Se into the proteins apparently enhances this activity. Thus, it appears that the immune-regulation activities of both Se and the proteins from G. lucidum can be combined.
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Siwulski Marek, Budzyńska Sylwia, Rzymski Piotr, Gąsecka Monika, Niedzielski Przemysław, Kalač Pavel, Mleczek Mirosław, The effects of germanium and selenium on growth, metalloid accumulation and ergosterol content in mushrooms: experimental study in Pleurotus ostreatus and Ganoderma lucidum, European Food Research and Technology, 245, 9, 2019. Crossref
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Raman Jegadeesh, Lakshmanan Hariprasath, Hyun-Jae Shin, Jang Kab-yel, The Nutritional and Pharmacological Potential of Medicinal Mushroom “Ganoderma lucidum (Lingzhi or Reishi)”, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref
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Liu Hao, Wang Zi-Ying, Zhou Yu-Cong, Song Wei, Ali Usman, Sze Daniel M.-Y, Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review, Journal of Ethnopharmacology, 268, 2021. Crossref