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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i6.80
pages 559-564

Inhibition of Quorum Sensing in the Opportunistic Pathogenic Bacterium Chromobacterium violaceum by an Extract from Fruiting Bodies of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Higher Basidiomycetes)

Hu Zhu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Wei Liu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Baozhen Tian
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Huijun Liu
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China
Shoujiao Ning
Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266555, P.R. China

RÉSUMÉ

Extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, inhibited quorum sensing in Chromobacterium violaceum CV026. G. lucidum fruiting bodies were milled and extracted with ethyl acetate. The crude extract was dissolved in an appropriate concentration of methanol, sterilized by filtration through a 0.22-μm membrane filter, and added to Ch. Violaceum CV026 cultures, which were used as an indicator to monitor quorum sensing inhibition. Inhibitory activity was measured by quantifying violacein production using a microplate reader. Methanol-soluble compounds extracted from G. lucidum significantly inhibited quorum sensing-controlled behavior in Ch. Violaceum in a concentration-dependent manner. The results suggest that compounds in G. lucidum might be useful to control and handle detrimental infections caused by human, animal, and plant pathogens. Further studies are in progress in our lab to isolate the specific compounds from G. lucidum extract, evaluate them as quorum sensing inhibitors, and analyze their mechanism of action.


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