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Critical Reviews™ in Physical and Rehabilitation Medicine
SJR: 0.121 SNIP: 0.228 CiteScore™: 0.5

ISSN Imprimer: 0896-2960
ISSN En ligne: 2162-6553

Critical Reviews™ in Physical and Rehabilitation Medicine

DOI: 10.1615/CritRevPhysRehabilMed.2015014074
pages 35-41

Insulin Resistance and Tendinopathy

Adrian Barniak
University of Connecticut Physical Therapy Program, Storrs, Connecticut
Ted Fifield
University of Connecticut Physical Therapy Program, Storrs, Connecticut
Craig R. Denegar
University of Connecticut Physical Therapy Program, Storrs, Connecticut
Michael F. Joseph
University of Connecticut Physical Therapy Program, Storrs, Connecticut

RÉSUMÉ

Tendinopathy is most prevalent among males suffering from insulin resistance secondary to metabolic syndrome and type II diabetes mellitus. The mechanistic relationship between insulin resistance and the development of tendinopathy is not fully understood. Tendon tissue changes associated with insulin resistance include disruption of collagen cross-linking, alterations in proteoglycan synthesis, and the presence of advanced glycosylation end products. In this review we focus on the epidemiology of tendinopathy among insulin resistant populations and the potential mechanisms underlying tendon degeneration related to insulin resistance and related diseases.


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