RT Journal Article ID 0305c3a32987d330 A1 Kim, Kyungtae A1 Chun, Kyung-Hee A1 Suh, Pann-Ghill A1 Kim, In-Hoo T1 Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2011 FD 2011-11-10 VO 21 IS 3 SP 237 OP 254 K1 Helicobacter pylori K1 cell cycle K1 oncogene K1 tumor suppressor K1 miRNA K1 promoter methylation AB Gastric cancer remains the fourth most prevalent cancer and the second leading cause of cancer-related death in the world. The predominant form of gastric cancer is adenocarcinoma, which originates from glandular epithelium of the gastric mucosa. The major risk factors for gastric cancer include diet, individual genetic variation, and, most importantly, infection with Helicobacter pylori (H. pylori). Certain strains of H. pylori assisted by some of its virulence factors seem to play a critical role in gastric cancer development. Several of these H. pylori virulence factors, which influence cellular proliferation signaling, have been identified. In addition, changes in the expression of several cell proliferation regulating genes accompany or cause the progression of gastric cancer. These changes include modifications of cell cycle regulators, oncogene activation, tumor suppressor inactivation, and miRNA profile alterations. Many of these changes result from H. pylori infection, although their impact on the cellular proliferation system underlying gastric cancer development has not yet been fully elucidated. We review certain features of gastric cancer, the role of H. pylori infection in its etiology and pathogenesis, and gene expression changes during gastric carcinogenesis. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,15257a67548a2bb6,0305c3a32987d330.html