RT Journal Article
ID 0305c3a32987d330
A1 Kim, Kyungtae
A1 Chun, Kyung-Hee
A1 Suh, Pann-Ghill
A1 Kim, In-Hoo
T1 Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2011
FD 2011-11-10
VO 21
IS 3
SP 237
OP 254
K1 Helicobacter pylori
K1 cell cycle
K1 oncogene
K1 tumor suppressor
K1 miRNA
K1 promoter methylation
AB Gastric cancer remains the fourth most prevalent cancer and the second leading cause of cancer-related death in the world. The predominant form of gastric cancer is adenocarcinoma, which originates from glandular epithelium of the gastric mucosa. The major risk factors for gastric cancer include diet, individual genetic variation, and, most importantly, infection with Helicobacter pylori (H. pylori). Certain strains of H. pylori assisted by some of its virulence factors seem to play a critical role in gastric cancer development. Several of these H. pylori virulence factors, which influence cellular proliferation signaling, have been identified. In addition, changes in the expression of several cell proliferation regulating genes accompany or cause the progression of gastric cancer. These changes include modifications of cell cycle regulators, oncogene activation, tumor suppressor inactivation, and miRNA profile alterations. Many of these changes result from H. pylori infection, although their impact on the cellular proliferation system underlying gastric cancer development has not yet been fully elucidated. We review certain features of gastric cancer, the role of H. pylori infection in its etiology and pathogenesis, and gene expression changes during gastric carcinogenesis.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,15257a67548a2bb6,0305c3a32987d330.html