RT Journal Article ID 09c9e9e65905973d A1 Nosenko, Nadiya D. A1 Tarasenko, Larisa V. A1 Sinitsyn, Pyotr V A1 Sachynska, Olga V. A1 Ganzhiy, I. Yu. A1 Reznikov, Alexander G. T1 Hormonal Changes in Female Rats Exposed to Chronic Stress and Androgen Excess at Pubescence JF International Journal of Physiology and Pathophysiology JO IJPP YR 2013 FD 2013-06-13 VO 4 IS 1 SP 11 OP 16 K1 chronic stress K1 androgen excess K1 steroid hormones K1 pubescence K1 female rats AB The changes in the blood plasma corticosterone, testosterone and androstenedione levels, and their responses to acute stress (30-minute immobilization) were studied in female rats aged 35, 40 and 45 days, exposed to chronic stress (a daily 30-minute immobilization from the 35th to 45th day of life) and / or excess of exogenous androgens (subcutaneous implantation of testosterone-filled silastic capsules to 33 day-old rats) at pubescence. Control and experimental females in all age groups responded to acute stress by a significant elevation of corticosterone levels. At that, in the hyperandrogenized females aged 45 days, an activation level of the adrenal glands decreased in response to acute dosed stress, but it increased gradually in the stressed rats. After acute stress, the blood plasma content of testosterone decreased in control 35 day-old females and increased in androgenized animals of the same age against a ten-fold increase in the basal hormone level. In both control females aged 40 days and androgenized ones exposed to chronic stress for 5 days, acute dosed stress did not result in significant changes in the blood plasma testosterone levels, while it increased androstenedione content. In the exposed to stress 40 day-old females, on the background of increased basal androstenedione secretion, the hormone response to acute stress did not change, whereas that of testosterone significantly decreased. At the end of puberty, plasma testosterone in both control and experimental animals aged 45 days did not change in response to acute dosed stress, but it decreased in stressed females, and increased against elevated basal hormone secretion in rats with hyperandrogenism, which were exposed to chronic stress. The conclusion has been made about the possible functional relationship between the changes in hormonal homeostasis during pubescence and the development of the reproductive system disorders in mature animals. PB Begell House LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,4b175c6838d9499f,09c9e9e65905973d.html