RT Journal Article
ID 0df6fa612762ffb5
A1 Zeng, Jie
A1 Xie, Longxiang
A1 Luo, Hongping
A1 Xie, Jianping
T1 The Epigenetic Modifications of Genes Associated with Tuberculosis Susceptibility and Implications for Epi-Drugs
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2015
FD 2015-11-10
VO 25
IS 4
SP 349
OP 362
K1 tuberculosis
K1 epigenetic
K1 susceptibility
AB Epigenetics of genes associated with tuberculosis susceptibility such as DNA methylation, posttranslational histone modifications, and non-coding RNA remain largely untapped field for better tuberculosis control. Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. Our summary of these modifications provides fresh insights into the pathogenesis of tuberculosis and inspires targets discovery for host-derived therapy.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,54a2f639520818b3,0df6fa612762ffb5.html