RT Journal Article
ID 0fa1fd095d464c12
A1 Elangovan, Perumal
A1 Jalaludeen, Abdulkadhar Mohamed
A1 Ramakrishnan, Ramalingam
A1 Pari, Leelavinothan
T1 Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2016
FD 2016-07-28
VO 35
IS 2
SP 133
OP 146
K1 troxerutin
K1 testis
K1 testicular toxicity
K1 nickel
K1 antioxidant
K1 oxidative stress
AB Nickel (Ni)-induced oxidative damage is a serious problem that leads to reproductive system failure through testicular damage. The present investigation was carried out to determine the effect of troxerutin (Txn) on testicular toxicity induced by Ni in experimental rat testes. The oral administration of Txn (100 mg/kg body weight [bw]) showed a significant (p < 0.01) increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione, ascorbate, total sulphydryl groups, and testis−organ weight. Subsequently, the administration of Txn also significantly reduced the accumulation of Ni, lipid peroxidation products, and protein carbonyl levels in Txn-treated animals. Testicular protection in the experimental animals by Txn is further substantiated by a remarkable reduction of Ni, which was revealed through testicular tissue histopathology. These studies suggest that Txn could prevent oxidative damage and testicular toxicity induced by Ni in experimental animals.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,0fa1fd095d464c12.html