RT Journal Article ID 0fa1fd095d464c12 A1 Elangovan, Perumal A1 Jalaludeen, Abdulkadhar Mohamed A1 Ramakrishnan, Ramalingam A1 Pari, Leelavinothan T1 Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2016 FD 2016-07-28 VO 35 IS 2 SP 133 OP 146 K1 troxerutin K1 testis K1 testicular toxicity K1 nickel K1 antioxidant K1 oxidative stress AB Nickel (Ni)-induced oxidative damage is a serious problem that leads to reproductive system failure through testicular damage. The present investigation was carried out to determine the effect of troxerutin (Txn) on testicular toxicity induced by Ni in experimental rat testes. The oral administration of Txn (100 mg/kg body weight [bw]) showed a significant (p < 0.01) increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione, ascorbate, total sulphydryl groups, and testis−organ weight. Subsequently, the administration of Txn also significantly reduced the accumulation of Ni, lipid peroxidation products, and protein carbonyl levels in Txn-treated animals. Testicular protection in the experimental animals by Txn is further substantiated by a remarkable reduction of Ni, which was revealed through testicular tissue histopathology. These studies suggest that Txn could prevent oxidative damage and testicular toxicity induced by Ni in experimental animals. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,0fa1fd095d464c12.html