RT Journal Article
ID 17133f83644e9f00
A1 Gershkovich, Pavel
A1 Wasan, Kishor M.
A1 Barta, Cheri A.
T1 A Review of the Application of Lipid-Based Systems in Systemic, Dermal/ Transdermal, and Ocular Drug Delivery
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2008
FD 2008-12-20
VO 25
IS 6
SP 545
OP 584
AB The introduction of combinatorial chemistry and the development of high-throughput techniques has significantly increased the amount of new active lipophilic molecular entities. As a result, the need for successful delivery of these lipophilic active compounds has also increased. One such method of delivery is through the use of advanced lipid-based drug delivery systems. Traditionally, the majority of reviews of lipid-based drug delivery systems were based on the oral administration field only. This review article focuses on the use of lipids in parenteral, dermal/ transdermal, and ocular drug delivery systems. Specific needs, considerations, approaches, and limitations in lipid-based drug delivery are discussed herein on the basis of the anatomical and physiological diversity of the target organs and systems.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,6d9016640bf024d0,17133f83644e9f00.html