RT Journal Article ID 2e6782c176a14595 A1 Dai, Yunkai A1 Foley, Ann T1 Tissue Engineering Approaches to Heart Repair JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2014 FD 2014-12-10 VO 42 IS 3-4 SP 213 OP 227 K1 ?ardiomyocytes K1 cardiac progenitors K1 pluripotent cells K1 hydrogels K1 engineered heart tissues AB The heart is a large organ containing many cell types, each of which is necessary for normal function. Because of this, cardiac regenerative medicine presents many unique challenges. Because each of the many types of cells within the heart has unique physiological and electrophysiological characteristics, donor cells must be well matched to the area of the heart into which they are grafted to avoid mechanical dysfunction or arrhythmia. In addition, grafted cells must be functionally integrated into host tissue to effectively repair cardiac function. Because of its size and physiological function, the metabolic needs of the heart are considerable. Therefore grafts must contain not only cardiomyocytes but also a functional vascular network to meet their needs for oxygen and nutrition. In this article we review progress in the use of pluripotent stem cells as a source of donor cardiomyocytes and highlight current unmet needs in the field. We also examine recent tissue engineering approaches integrating cells with various engineered materials that should address some of these unmet needs. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,4103b71326f54ce4,2e6782c176a14595.html