RT Journal Article ID 3c0348151168996e A1 Suzuki, Motohiko A1 Zheng, Xiufen A1 Zhang, Xusheng A1 Zhang, Yuwei A1 Ichim, Thomas E. A1 Min, Weiping T1 Regulation of Allergy with RNA Interference JF Critical Reviews™ in Immunology JO CRI YR 2009 FD 2010-02-02 VO 29 IS 6 SP 443 OP 468 K1 allergy K1 immune modulation K1 immunotherapy K1 gene silencing K1 siRNA K1 RNA interference AB Allergic diseases such as asthma, allergic rhinitis, allergic conjunctivitis, and atopic dermatitis are clinically challenging. Although current treatments such as antihistamines, leukotriene receptor antagonists, and corticosteroids are effective at reducing symptoms, they do not address the underlying cause of the allergic response. Therefore, novel therapies that target upstream causative events in allergic diseases are desirable. The induction of RNA interference (RNAi) by small interfering RNA (siRNA) is a potent method for specifically knocking down molecular targets. Gene modulation by siRNA is therapeutically promising, with clinical safety and feasibility already demonstrated. However, to our knowledge, the use of siRNA in the area of allergic disease has been limited. Recently, we demonstrated the inhibition of CD40 by siRNA as a means of inhibiting allergic reactions. RNAi-based therapies represent a novel and promising strategy for the control of both the symptoms of allergy and the cause of the allergic response. Here we discuss the potential of siRNA in the treatment of allergic diseases by focusing on molecular and cellular interactions involved in the allergic cascade. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e9e83c77713325b,3c0348151168996e.html