%0 Journal Article
%A Wang, Junzhi
%A Sun, Wenjun
%A Luo, Huajun
%A He, Haibo
%A Deng, Wei-Qiao
%A Zou, Kun
%A Liu, Can
%A Song, Jing
%A Huang, Wenfeng
%D 2015
%I Begell House
%K medicinal mushrooms, eburicoic acid, gastric ulcer, H+/K+-ATPase
%N 7
%P 619-626
%R 10.1615/IntJMedMushrooms.v17.i7.20
%T Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice
%U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,05ab5a7e40e7ba9a,3d59c4b4618e115d.html
%V 17
%X In this study, we investigated the anti-inflammatory and tumor-inhibiting effects of eburicoic acid, the main bioactive component in the Laetiporus sulphureus, on gastric ulcers. A total of 48 Kunming mice were randomly divided into six groups: control, model, OL (omeprazole, 20 mg/kg/day, orally), EA-L (eburicoic acid, 10 mg/kg/day, orally), EA-M (eburicoic acid, 20 mg/kg/day, orally), and EA-H (eburicoic acid, 40 mg/kg/day, orally). Gastric ulcers were induced in mice by administering 80% ethanol containing 15 mg/mL aspirin (10.0 mL/kg, i.g.) 4 hours after drug administration on day 5. The ulcer index and H+/K+-ATPase activity were evaluated in vivo. Computer-aided molecular docking simulated the interaction between eburicoic acid and H+/K+-ATPase. The results showed that the oral administration of eburicoic acid protected the gastric mucosa from gastric lesions morphologically and especially attenuated H+/K+-ATPase activity. The results of this study indicate that the gastric protective effect of eburicoic acid might inhibit gastric acid.
%8 2015-10-09