%0 Journal Article %A Wang, Junzhi %A Sun, Wenjun %A Luo, Huajun %A He, Haibo %A Deng, Wei-Qiao %A Zou, Kun %A Liu, Can %A Song, Jing %A Huang, Wenfeng %D 2015 %I Begell House %K medicinal mushrooms, eburicoic acid, gastric ulcer, H+/K+-ATPase %N 7 %P 619-626 %R 10.1615/IntJMedMushrooms.v17.i7.20 %T Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,05ab5a7e40e7ba9a,3d59c4b4618e115d.html %V 17 %X In this study, we investigated the anti-inflammatory and tumor-inhibiting effects of eburicoic acid, the main bioactive component in the Laetiporus sulphureus, on gastric ulcers. A total of 48 Kunming mice were randomly divided into six groups: control, model, OL (omeprazole, 20 mg/kg/day, orally), EA-L (eburicoic acid, 10 mg/kg/day, orally), EA-M (eburicoic acid, 20 mg/kg/day, orally), and EA-H (eburicoic acid, 40 mg/kg/day, orally). Gastric ulcers were induced in mice by administering 80% ethanol containing 15 mg/mL aspirin (10.0 mL/kg, i.g.) 4 hours after drug administration on day 5. The ulcer index and H+/K+-ATPase activity were evaluated in vivo. Computer-aided molecular docking simulated the interaction between eburicoic acid and H+/K+-ATPase. The results showed that the oral administration of eburicoic acid protected the gastric mucosa from gastric lesions morphologically and especially attenuated H+/K+-ATPase activity. The results of this study indicate that the gastric protective effect of eburicoic acid might inhibit gastric acid. %8 2015-10-09