%0 Journal Article %A Peleg, Sara %D 2007 %I Begell House %N 2 %P 149-158 %R 10.1615/CritRevEukarGeneExpr.v17.i2.40 %T Responsiveness of Osteoblastic and Osteolytic Bone Metastases to Vitamin D Analogs %U https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,31c5e2d111e631ad,4923aec130567690.html %V 17 %X Bone is the primary site of metastases in advanced androgen-independent prostate cancer. These metastases are primarily bone-forming, although the presence of osteolytic response has also been reported. Bone-homing therapy is a strategy based on the popular seed-and-soil relationship between the epithelial malignant cells and the bone stroma. Calcitriol (1,25-dihydroxyvitamin D3) and its synthetic analogs (deltanoids) are drugs that have a direct effect on both the skeleton and the invading metastatic cells and, therefore, are considered useful in the treatment of advanced prostate cancer. In this article, I review the nature of the response induced by the malignant cells in the bone (bone formation or bone resorption) and how it affects the outcome of a vitamin D analog treatment in preclinical models of metastatic bone disease. %8 2007-05-21