RT Journal Article ID 566d28236ada5906 A1 Kaur, Gurpreet A1 Lone, Irshad A. A1 Athar, Mohammad A1 Alam, Sarwar M. T1 Guilandina bonduc L. Possesses Antioxidant Activity and Precludes Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Toxicity and Tumor Promotion Response JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2009 FD 2009-10-05 VO 28 IS 2 SP 163 OP 175 K1 Guilandina bonduc K1 ferric nitrilotriacetate K1 tumor promotion K1 oxidative stress K1 antioxidant AB Guilandina bonduc Linn. (Fabaceae), a prickly shrub that grows abundantly in tropical and subtropical regions of Southeast Asia, possesses an extensive medicinal value. The present communication reports ethanolic extract of G. bonduc fruit pods to possess potent antioxidant activity and significantly protect against Ferric Nitrilotriacetate (Fe-NTA)−induced renal oxi-dative stress, nephrotoxicity, and tumor promotion response. Intraperitoneal administration of Fe-NTA (9 mg Fe/Kg body weight) to Swiss albino mice depleted renal antioxidant armory (glutathione content and activities of antioxidant enzymes), and caused oxidative stress, induced inflammation (inducing the expression of inducible nitric oxide synthase and cyclooxygenase-2 and increasing the secretion of proinflammatory cytokines). It also induced hyperproliferation in kidney-enhancing ornithine decarboxylase (ODC) activity and [3H]-thymidine incorporation into DNA. Histopathological changes and levels of serum creatinine (SCr) and blood urea nitrogen (BUN) suggested Fe-NTA to afflict substantial damage to the kidney. Prophylactic treatment of mice with G. bonduc extract (100−200 mg /Kg body weight) for seven days not only restored renal antioxidant armory close to normal, but also significantly precluded Fe-NTA associated inflammation and hyperproliferation. Furthermore, pretreatment with extract markedly prevented renal oxidative damage and histopathological alterations, and restored the levels of renal damage markers close to control values. The data obtained in the present study indicate G. bonduc fruit pods to possess a potent antioxidant activity and avert chemically inflicted renal oxidative damage and tumor promotion response. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,5b2ee8f13327d597,566d28236ada5906.html