RT Journal Article
ID 566d28236ada5906
A1 Kaur, Gurpreet
A1 Lone, Irshad A.
A1 Athar, Mohammad
A1 Alam, Sarwar M.
T1 Guilandina bonduc L. Possesses Antioxidant Activity and Precludes Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Toxicity and Tumor Promotion Response
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2009
FD 2009-10-05
VO 28
IS 2
SP 163
OP 175
K1 Guilandina bonduc
K1 ferric nitrilotriacetate
K1 tumor promotion
K1 oxidative stress
K1 antioxidant
AB Guilandina bonduc Linn. (Fabaceae), a prickly shrub that grows abundantly in tropical and subtropical regions of Southeast Asia, possesses an extensive medicinal value. The present communication reports ethanolic extract of G. bonduc fruit pods to possess potent antioxidant activity and significantly protect against Ferric Nitrilotriacetate (Fe-NTA)−induced renal oxi-dative stress, nephrotoxicity, and tumor promotion response. Intraperitoneal administration of Fe-NTA (9 mg Fe/Kg body weight) to Swiss albino mice depleted renal antioxidant armory (glutathione content and activities of antioxidant enzymes), and caused oxidative stress, induced inflammation (inducing the expression of inducible nitric oxide synthase and cyclooxygenase-2 and increasing the secretion of proinflammatory cytokines). It also induced hyperproliferation in kidney-enhancing ornithine decarboxylase (ODC) activity and [3H]-thymidine incorporation into DNA. Histopathological changes and levels of serum creatinine (SCr) and blood urea nitrogen (BUN) suggested Fe-NTA to afflict substantial damage to the kidney. Prophylactic treatment of mice with G. bonduc extract (100−200 mg /Kg body weight) for seven days not only restored renal antioxidant armory close to normal, but also significantly precluded Fe-NTA associated inflammation and hyperproliferation. Furthermore, pretreatment with extract markedly prevented renal oxidative damage and histopathological alterations, and restored the levels of renal damage markers close to control values. The data obtained in the present study indicate G. bonduc fruit pods to possess a potent antioxidant activity and avert chemically inflicted renal oxidative damage and tumor promotion response.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,5b2ee8f13327d597,566d28236ada5906.html