%0 Journal Article %A Schutzer, Steven E. %A Coyle, P. K. %D 2016 %I Begell House %K Borrelia, Lyme disease , immune complexes %N 3-4 %P 213-224 %R 10.1615/ForumImmunDisTher.2017019621 %T Immune Complex Analysis in Active Lyme Disease %U https://www.dl.begellhouse.com/journals/2c6306423483e001,6deddb8911c6adff,583be4ad20451fd6.html %V 7 %X Lyme disease (LD) is a growing infectious disease. Assays that can detect active infection early are needed to allow appropriate antibiotic therapy to begin when there is the best chance for a cure. The most frequently used assays are those based on antibodies to Borrelia burgdorferi or its variants, the causative agent of LD. However, an antibody test at a single time point only measures exposure, not necessarily an active infection. In contrast, antibodies that are bound to a target antigen in a circulating immune complex form do indicate active infection. Here, we present data supporting the use of such assays in LD. %8 2017-10-11