RT Journal Article
ID 5d9306f871216e4d
A1 Chouaib, Salem
A1 Janji, Bassam 
A1 Tittarelli, Andres
A1 Eggermont, Alexander 
A1 Thiery, Jean Paul 
T1 Tumor Plasticity Interferes with Anti-Tumor Immunity
JF Critical Reviews™ in Immunology
JO CRI
YR 2014
FD 2014-04-02
VO 34
IS 2
SP 91
OP 102
K1 Immunosurveillance
K1 evasion
K1 phenotypic plasticity
K1 tumor microenvironment
K1 EMT
AB Since tumor cell plasticity was first shown to be crucial in tumor promotion and immune surveillance evasion, it has become an issue of intense investigation. Several mechanisms are associated with the acquisition of tumor cell plasticity and immune evasion, including loss of epithelial phenotype through epithelial-to-mesenchymal transition (EMT). We discuss recent evidence revealing that tumor cell plasticity may lead to the emergence of immunoresistant variants and how the tumor microenvironment evolves to shape this plasticity. We argue that targeting carcinoma cell plasticity represents a novel strategy to better control the emergence of resistant variants and to ensure more effective cancer therapies. In this context, the design of innovative integrative immunotherapy approaches is warranted.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,6fd3c75b68d49e79,5d9306f871216e4d.html