RT Journal Article ID 71093e9122af695b A1 Yatsenko, Kateryna V. A1 Berezovskiy, Vadim A. A1 Deyeva, J. V. T1 Effects of Intermittent Normobaric Hypoxia on the CNS Functions and Cerebral Circulation in Children with Cerebral Palsy JF International Journal of Physiology and Pathophysiology JO IJPP YR 2013 FD 2013-06-13 VO 4 IS 1 SP 27 OP 36 K1 cerebral palsy K1 intermittent normobaric hypoxia K1 adaptation AB We studied the effects of intermittent normobaric hypoxia (INH) on the CNS functions and cerebral circulation recovery in children with cerebral palsy (CP). Altogether, 87 patients (from 8.5 months to 12 years old) with CP were examined and received the course of complex treatment. Clinico-neurophysiological examination was performed before the treatment and immediately after termination of the therapeutic course. Patients were divided into two randomized groups according to age, sex and clinical manifestations of CP. The comparison group included 34 children who received the course of the generally accepted complex therapy (medicamental treatment, massage, Bobat-therapy, Vojta-therapy at al). The main group included 53 patients who, in addition to the same therapy, were exposed to INH using an individual apparatus for artificial mountain air, Borey-M, made in the Scientific Medico-Engineering Center NORT (Ukrainian National Academy of Sciences, Kyiv). Children of the main group were exposured to the dosed normobaric intermittent hypoxia at sanogenetic level once per day. For this purpose, we used a normobaric hypoxic gas mixture (12% O2 + 88% N2). Each cycle included a 15-min-long episode of breathing with the gas mixture alternated by a 5-min-long episode of breathing with an ambient atmospheric air. The number of hypoxic cycles was gradually increased (from one to three). The entire course of treatment included 10 sessions, on average. After complex therapy, the stable positive effects on the motor status were observed in 94% of patients of the main group (exposed to INH) and in 74% of patients of the comparison group (unexposed to INH). EEG examination showed positive dynamics in patients of both the main group (70%) and in children of the comparison group (56%). Doppler examination showed that brain hemodynamics was normalized in 85% of patients of the main group and in 59% of children in the comparison group. In the course of ophthalmoscopic examination, positive changes in the state of the eye fundus were found more expressed in children of the main group, compared to those in patients of the comparison group (32% and 12% of patients, respectively). PB Begell House LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,4b175c6838d9499f,71093e9122af695b.html