RT Journal Article
ID 765d4b113c244bd0
A1 Leclercq , Georges 
A1 Plum, Jean 
T1 Expression and Function of Fc Receptors in the Thymus
JF Critical Reviews™ in Immunology
JO CRI
YR 1995
FD 1995-12-01
VO 15
IS 3-4
SP 215
OP 233
K1 CD 16
K1 CD23
K1 CD32
K1 γ chain
K1 ζ chain
K1 deficient mice
AB In this review, the expression and function of Fc receptors (FcRs) in the thymus is discussed. In the murine thymus, FcγRII and FcγRIII are expressed on early thymocyte precursors, which can differentiate in both T and NK cells. TCR αβ thymocytes that are differentiating along the CD4-CD8 pathway do not express FcγRs any longer. Mature CD4-CD8 double negative TCR αβ and TCR Vγ3 cells, however, constitutively express FcγRII/III. The generation of gene-deficient mice has shown that neither FcγRs nor FcεRII are indispensable for murine thymus-dependent T cell development, whereas normal development of thymus-independent peripheral T cells is dependent on the presence of the FcRγ chain. In the human thymus, a low number of CD3-CD4-CD8 triple negative cells expresses FcγRIII, but these cells are mainly NK cells. FcεRII is expressed on human thymic epithelial cells. Although the unaltered thymic development of T cells in FcR-deficient mice argues against a fundamental role of FcRs in this process, recent demonstration of FcR ligands of non-immunoglobulin nature in the thymus indicates that the interaction between FcRs and their ligands in the thymus might influence T cell development.

PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,601751ce468f47e1,765d4b113c244bd0.html