%0 Journal Article %A Lee, Hyun Ah %A Kim, Hyunung %A Lee, Kwang-Won %A Park, Kun-Young %D 2016 %I Begell House %K dietary nanosized Lactobacillus plantarum, kimchi, colitis-associated colorectal cancer, C57BL/6J mouse %N 2 %P 147-159 %R 10.1615/JEnvironPatholToxicolOncol.2016015633 %T Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium−Induced Colon Cancer in C57BL/6J Mice %U https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,780065997da8f33a.html %V 35 %X This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.)plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)−induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. Plantarum isolated from kimchi that is 0.5−1.0 µm in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry. %8 2016-07-28