RT Journal Article
ID 7814b2721043aba5
A1 Jia, Wei
A1 Feng, Jie
A1 Zhang, Jingsong
A1 Lin, Chi-Chung
A1 Wang, Wenhan
A1 Chen, Hong-Ge
T1 Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-09-12
VO 19
IS 6
SP 535
OP 546
K1 Flammulina velutipes
K1 FVPA1 polysaccharide
K1 medicinal mushrooms
K1 NK cell activity
K1 NMR
K1 structural
characterization
AB FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom
Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive
taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a number of essential
biological activities. The average molecular weight was estimated to be ~1.8 × 104 Da based on high-performance
size exclusion chromatography. Sugar analyses, methylation analyses, and 1H, 13C, and 2-dimensional nuclear magnetic
resonance spectroscopy revealed the following structure of the repeating units of the FVPA1 polysaccharide
Identification of this structure would conceivably lead to better understanding of the nutraceutical functions of this
very important edible fungus. Bioactivity tests in vitro indicated that FVPA1 could significantly enhance natural killer cell activity against K562 tumor cells.
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