RT Journal Article ID 7a9f3b85400973c1 A1 Hill, Jacob A1 Hodsdon, Wendy T1 In Utero Exposure and Breast Cancer Development: an Epigenetic Perspective JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2014 FD 2014-07-21 VO 33 IS 3 SP 239 OP 245 K1 genetics K1 epigenetics K1 oncology K1 nutrition K1 toxicology K1 pregnancy K1 environment AB The ubiquitous and detrimental disease of breast cancer requires continual research into new and alternative forms of treatment and prevention. The emerging field of epigenetics is beginning to unfold an array of contemporary approaches to reduce the risk and improve the clinical approach to breast cancer. The information contained in this non-systematic review highlights and expands on the estrogen-based model of breast cancer epigenetics to provide an overview of epigenetic alterations induced by nutrition and environmental exposure. The majority of evidence suggests that various sources of excess estrogen correlate to future breast cancer development. In addition, maternal macro- and micronutrient balance appear to play a role in genomic regulation, and preliminary data suggest that specific superfoods, such as blueberries, have a protective epigenetic effect. Identifying the influence of environmental toxicants, hormonal exposure, maternal nutrition, and maternal disease on fetal epigenetics may have potential for development of new therapeutic approaches for the prevention of breast cancer. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,0410fa476f5ceb7e,7a9f3b85400973c1.html