RT Journal Article ID 7c7481e3431c3db0 A1 Pan, Honghui A1 Lei, Suwei A1 Zhao, Xiaojie A1 Xie, Yi-Zhen A1 Yang, Xiaobing T1 Activation of the AKT/FOXO3a Signaling Pathway during Breast Cancer Inhibition In Vivo and In Vitro by Amauroderma rude (Agaricomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2019 FD 2020-01-07 VO 21 IS 12 SP 1151 OP 1165 K1 Amauroderma rude K1 antitumor K1 FOXO3a K1 medicinal mushrooms K1 p-AKT AB We previously reported that Amauroderma rude polysaccharides (AR) displayed strong immunomodulatory tumor-suppressive effects in mice. The current study was designed to explore the potential mechanism by which AR polysaccharides inhibit tumor growth. We found that AR could effectively induce cell death in 4T1 and MDA-MB-231 breast cancer cells. AR could also inhibit tumor cell migration and invasion, significantly promote apoptosis in 4T1 cells, and significantly increase CDK4, CDK6, cylinD1, and P27 mRNA expression in mice. Additionally, AR was able to significantly increase FOXO3a expression and decrease p-AKT expression both in vitro and in vivo, indicating that the AKT/FOXO3a signaling pathway had been activated during the inhibitory process. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6f06ece20ea6c85f,7c7481e3431c3db0.html