Abonnement à la biblothèque: Guest
TSFP DL Home Archives Comité de direction

METHODS FOR UNDERSTANDING SHEAR INDUCED THROMBUS GROWTH

Isaac Pinar
Department of Mechanical and Aerospace Engineering Monash University Wellington Rd, Clayton, Victoria, 3800 Australia

Jane Arthur
Australian Centre for Blood Diseases Monash University 89 Commercial Rd, Melbourne, Victoria, 3004 Australia

Rob Andrews
Australian Centre for Blood Diseases Monash University 89 Commercial Rd, Melbourne, Victoria, 3004 Australia

Elizabeth Gardiner
Australian Centre for Blood Diseases Monash University 89 Commercial Rd, Melbourne, Victoria, 3004 Australia

Kris Ryan
Department of Mechanical and Aerospace Engineering Monash University Wellington Rd, Clayton, Victoria, 3800 Australia

Josie Carberry
Department of Mechanical and Aerospace Engineering Monash University Wellington Rd, Clayton, Victoria, 3800 Australia

Résumé

The formation of blood clots is a key process in preventing major blood loss. Novel techniques are presented that allow for both the quantitative and qualitative analysis of shear dependent thrombus formation in real-time. Techniques that allow for scanned real-time images to be time corrected and reconstructed into a three-dimensional (3D) surface are demonstrated. As past work has demonstrated platelet activation and the subsequent thrombus growth is highly shear sensitive (Nesbitt, 2009). In order to attain better understanding to the underlying mechanisms driving thrombus formation the novel techniques presented allow for the shear history of individual platelets to be correlated with factors such as overall thrombus growth. A combination of the methods presented provides a powerful tool towards analysing thrombus growth in a highly temporal and spatially accurate manner.