Begell House Inc.
Plasma Medicine
PMED
1947-5764
10
2
2020
Optical and Electrical Characteristics of an Endoscopic DBD Plasma Jet
71-90
10.1615/PlasmaMed.2020034526
Orianne
Bastin
Bio-, Electro-, and Mechanical Systems (BEAMS), Biomed Group, Ecole Polytechnique de Bruxelles, Brussels, Belgium
Max
Thulliez
Bio-, Electro-, and Mechanical Systems (BEAMS), Biomed Group, Ecole Polytechnique de Bruxelles, Brussels, Belgium
Jean
Servais
Bio-, Electro-, and Mechanical Systems (BEAMS), Biomed Group, Ecole Polytechnique de Bruxelles, Brussels, Belgium
Antoine
Nonclercq
Bio-, Electro-, and Mechanical Systems (BEAMS), Biomed Group, Ecole Polytechnique de Bruxelles, Brussels, Belgium
Alain
Delchambre
Bio-, Electro-, and Mechanical Systems (BEAMS), Biomed Group, Ecole Polytechnique de Bruxelles, Brussels, Belgium; Department of Applied Mechanics - University of Brussels (ULB)
Alia
Hadefi
Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, C.U.B. Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
Jacques
Devière
Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, C.U.B. Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
François
Reniers
Chemistry of Surfaces, Interfaces, and Nanomaterials, ChemSIN, Université Libre de Bruxelles, Faculty of Sciences, Brussels, Belgium
cold atmospheric plasma
electrical characterization
optical characterization
plasma jet
endoscopy
dielectric barrier discharge
In this work, a new cold plasma source design capable of generating and transporting a plasma jet over long distances (2 m) is presented with the purpose of being used in flexible endoscopy for treatment within the gastrointestinal tract. This dielectric barrier discharge helium plasma jet consists of a polytetrafluoroethylene capillary connected to a quartz chamber around which a copper electrode is wrapped. A copper wire is freely inserted inside the capillary. The applied voltage is a conventional AC 18-kHz signal to drive the discharge. In order to develop a safe and predictable treatment, a robust and reliable electrical model is necessary and we hypothesized that plasma transport can be modeled as a transmission line. We therefore assessed the electrical behavior of our new cold plasma source. As it is known that the target to which the plasma jet is applied drastically changes the behavior of the plasma itself, an electrical substitute simulating the impedance of a human body is introduced into the circuit, and the plasma behavior is then compared to the free-jet configuration. The effects of the input power (from 10 W to 80 W), and the length of the jet (from 60 cm to 220 cm) were investigated, as well as the electrical changes induced by the presence of an endoscope. The results obtained show trend curves similar to our hypothetical model, although the latter is still only qualitative. This long plasma jet model represents a promising approach that can be used, after further refinement, for controllability of plasma jets for endoscopy applications.
Cold Atmospheric Plasma Prevents Wrinkle Formation via an Antiaging Process
91-102
10.1615/PlasmaMed.2020034810
Sang Gyu
Hwang
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
Jung Ho
Kim
Department of Teaching and Learning, School of Culture, Education, and Human Development, New York University, New York, NY 10003
Soo Youn
Jo
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
Young Jae
Kim
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
Chong Hyun
Won
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
cold atmospheric plasma
wrinkle
antiaging
collagen
MMP
skin
Cold atmospheric plasma is a material that generates free radicals through the ionization of air. Despite the application of this material in various medical fields, the precise mechanism underlying its effect at the cellular level is not fully understood. To date, it is known to stimulate the expression of antioxidant transcription factors such as nuclear factor erythroid 2-related factor 2 (Nrf2), forkhead box class O 3a (FOXO3a), and heme oxygenase 1 (HO-1). In this study, we aimed to assess whether and how cold atmospheric plasma affects damaged cells, particularly after exposure to UV radiation. We found that it can promote mitochondrial health by controlling the stability of the membrane potential of mitochondria against UV radiation. Moreover, cold atmospheric plasma prevents senescence in fibroblasts exposed to UV radiation through the upregulation of p53. It also exhibits hormetic effects (i.e., beneficial effects at low doses) on MMP and collagen in senescent fibroblasts exposed to UV radiation. In conclusion, cold atmospheric plasma treatment not only protects fibroblasts from free radicals but also represses the aging of these cells in a UV-radiation-induced aging process.
Suppression of Cooking Oil Deterioration by Electromagnetic Field with Harmonics Generated by Asymmetric Circuit
103-111
10.1615/PlasmaMed.2020034997
Masato
Kiuchi
Center for Atomic and Molecular Technologies, Osaka University, Osaka, Japan; D-invest Co. Ltd., Osaka, Japan
Tatsuji
Miyagawa
D-invest Co. Ltd., Osaka, Japan
antenna
harmonics
vegetable oil
degradant
gas chromatography
mass spec-trometry
The cooking oil used for frying foods degrades with use, producing degradants that adversely affect the taste and safety of the fried foods. Existing methods proposed to reduce this degradation either require the addition of chemicals or the use of expensive equipment. In this paper, we present a technique that suppresses oil degradation with no additional chemical or expensive device required. Specifically, the technique utilizes the electromagnetic field with harmonic noise produced by the antenna of an asymmetric electric circuit to suppress the deterioration of high-temperature vegetable oil. The electromagnetic harmonics are applied by immersing the working antenna directly in the hot oil during the cooking of various frozen foods. The degradants from vegetable oil heated with and without the harmonics, as well as with and without air bubbling, were analyzed by gas chromatography and mass spectrometry. The results indicate that application of the harmonics reduces the amount of produced oil degradants to less than one-third of that produced normally.
Modifying the Blood's Physical and Chemical Parameters Using Cold Helium Plasma: In Vitro Study
113-122
10.1615/PlasmaMed.2020036212
Andrew K.
Martusevich
Privolzhsky Research Medical University, Nizhny Novgorod, Russia; Nizhny Novgorod State Agricultural Academy, Nizhny Novgorod, Russia
Alexander G.
Galka
Privolzhsky Research Medical University, Nizhny Novgorod, 603950 Russia; Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod, 603950 Russia
Elena S.
Golygina
Privolzhsky Research Medical University, Nizhny Novgorod, 603950 Russia
cold helium plasma
biological activity
blood
dielectric properties
crystallization
We evaluate the modulating effect of helium cold plasma on crystallogenic and dielectric properties of blood plasma.
Plasma Jet-Treated Lidah Buaya (Aloe Vera) Influences Proliferative-Phase Wound Healing
123-138
10.1615/PlasmaMed.2020036388
Laela Hayu
Nurani
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia
Nasruddin
Nasruddin
Department of Clinical Laboratory Science, Universitas Muhammadiyah Semarang, Semarang, Indonesia; Interdisciplinary Research Laboratory for Experimental Plasma Medicine (iPlasmed), Universitas Muhammadiyah Semarang, Semarang, Indonesia; Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia
S.
Darmawati
Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia; Department of Medical Laboratory Science, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Indonesia; Interdisciplinary Research Laboratory for Experimental Plasma Medicine (iPlasmed), Universitas Muhammadiyah Semarang, Indonesia
Eka Sakti
Wahyuningtyas
Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia; Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Magelang, Indonesia
E. I.
Safitri
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Wahid Hasyim, Semarang, Indonesia
E.
Junita
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Y. D. A.
Ningrum
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
R. P.
Rahmawati
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
R. A.
Astuti
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
I. M.
Sikumbang
Department of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; Interdisciplinary Research Laboratory for Experimental Plasma Medicine (iPlasmed), Universitas Muhammadiyah Semarang, Indonesia; Department of Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Magelang, Magelang, Indonesia
A.
Kartikadewi
Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia; Interdisciplinary Research Laboratory for Experimental Plasma Medicine (iPlasmed), Universitas Muhammadiyah Semarang, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Semarang, Semarang, Indonesia
Y.
Sari
Department of Nursing, Universitas Jenderal Soedirman, Purwokerto, Indonesia
A. H.
Mukaromah
Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia; Department of Medical Laboratory Science, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Indonesia; Interdisciplinary Research Laboratory for Experimental Plasma Medicine (iPlasmed), Universitas Muhammadiyah Semarang, Indonesia; Research Center for Experimental Wound Healing, Universitas Muhammadiyah Magelang, Indonesia
D. C.
Anita
Muhammadiyah Research Network for Plasma Medicine (M-Plasmed), Semarang, Indonesia; Department of Nursing, Universitas Aisyiyah Yogyakarta, Yogyakarta, Indonesia
Tatsuo
Ishijima
Faculty of Electrical Information and Communication Engineering, Kanazawa University, Kakuma,
Kanazawa-shi, Japan
Toshio
Nakatani
Division of Nursing, Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa-shi, Japan
atmospheric plasma jet
plasma medicine
redox
plasma-activated water (PAW)
wound
aloe vera
gels
An in vivo experimental study was conducted to evaluate the effect of a plasma-treated aloe vera slice on cutaneous acute wound healing using a small animal model. A nonequilibrium atmospheric plasma pressure jet (N-APPJ) was developed. Aloe vera slices with thicknesses of approximately 2 mm were treated by N-APPJ at distances of 5 mm, 10 mm, and 20 mm before application. Possible reactive species on the surfaces of the plasma-treated aloe vera slices were chemically identified. Forty-five male Balb/c mice, aged 7−8 weeks, were classified into 5 groups: control (C), aloe vera slice alone (Av), plasma-treated aloe vera slice at 5-mm distance (PTAv-5), plasma-treated aloe vera slice at 10-mm distance (PTAv-10), and plasma-treated aloe vera slice at 20-mm distance (PAV-20). Wounds were observed for 14 days. Histological evaluation using general staining for re-epithelialization was also conducted. The "dropped-water method" was able to identify surfatic RONS. Additionally, this investigation revealed that sizes of wound areas in groups containing an aloe vera slice, from days 2 to 14, were significantly smaller compared with the control group. During the proliferative phase, wound size in PTAv-20 was smaller than that in both PTAv-5 and PTAv-10. From days 4 to 7, wound size in PTAv-20 was slightly smaller than that in Av; however, wound size in PTAv-5 and PTAv-10 was greater than that in PTAv-20. On day 7, re-epithelialization percentages in Av and PTAv-20 were significantly higher than in C. It was concluded that plasma-treated aloe vera has the ability to influence the proliferative phase of wound healing.